5-Bromo-N,N-dimethylisoquinolin-1-amine | 1330755-16-2

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 喹啉及其衍生物
• 英文名称: 5-Bromo-N,N-dimethylisoquinolin-1-amine
• CAS: 1330755-16-2
• 化学式: C₁₁H₁₁BrN₂
• 分子量: 251.12
• InChiKey: LHNAJJIILVZUEE-UHFFFAOYSA-N

物化性质

• 沸点：
  331.8±27.0 °C(Predicted)
• 密度：
  1.468±0.06 g/cm3(Predicted)

计算性质

• 辛醇/水分配系数(LogP)：
  3.2
• 重原子数：
  14
• 可旋转键数：
  1
• 环数：
  2.0
• sp3杂化的碳原子比例：
  0.18
• 拓扑面积：
  16.1
• 氢给体数：
  0
• 氢受体数：
  2

文献信息

• INHIBITORS OF SARM1 IN COMBINATION WITH NEURO-PROTECTIVE AGENTS
  申请人：Disarm Therapeutics, Inc.

  公开号：US20220008405A1

  公开（公告）日：2022-01-13

  The present disclosure relates to methods of treating neurodegeneration and neurodegenerative diseases comprising administering to a subject in need thereof a combination of a SARM1 inhibitor and a neuroprotective agent.
• INHIBITORS OF SARM1 IN COMBINATION WITH NAD+ OR A NAD+ PRECURSOR
  申请人：Disarm Therapeutics, Inc.

  公开号：US20220072019A1

  公开（公告）日：2022-03-10

  The present disclosure relates to methods of treating neurodegeneration and neurodegenerative diseases comprising administering to a subject in need thereof a combination of a SARM1 inhibitor and NAD+ or a NAD+ precursor.
• [EN] INHIBITORS OF SARM1 IN COMBINATION WITH NAD+ OR A NAD+ PRECURSOR<br/>[FR] INHIBITEURS DE SARM1 EN COMBINAISON AVEC NAD+ OU UN PRÉCURSEUR DE NAD+
  申请人：DISARM THERAPEUTICS INC

  公开号：WO2020081923A1

  公开（公告）日：2020-04-23

  The present disclosure relates to methods of treating neurodegeneration and neurodegenerative diseases comprising administering to a subject in need thereof a combination of a SARM1 inhibitor and NAD+ or a NAD+ precursor.
• [EN] INHIBITORS OF SARM1 IN COMBINATION WITH NEUROPROTECTIVE AGENTS<br/>[FR] INHIBITEURS DE SARM1 EN COMBINAISON AVEC DES AGENTS NEUROPROTECTEURS
  申请人：DISARM THERAPEUTICS INC

  公开号：WO2020132045A1

  公开（公告）日：2020-06-25

  The present disclosure relates to methods of treating neurodegeneration and neurodegenerative diseases comprising administering to a subject in need thereof a combination of a SARM1 inhibitor and a neuroprotective agent.