N-(2-pentacosa-10,12-diynoylaminoethyl)-N-(N⁶-(benzyloxycarbonyl)adenin-9-ylacetyl)glycine methyl ester | 625442-91-3

• 分子结构分类: 有机化合物 - 有机酸及其衍生物 - 羧酸及其衍生物
• 英文名称: N-(2-pentacosa-10,12-diynoylaminoethyl)-N-(N⁶-(benzyloxycarbonyl)adenin-9-ylacetyl)glycine methyl ester
• 英文别名: Methyl 2-[2-(pentacosa-10,12-diynoylamino)ethyl-[2-[6-(phenylmethoxycarbonylamino)purin-9-yl]acetyl]amino]acetate
• CAS: 625442-91-3
• 化学式: C₄₅H₆₃N₇O₆
• 分子量: 798.039
• InChiKey: LWTMMEJEBKQXSX-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  10.7
• 重原子数：
  58
• 可旋转键数：
  31
• 环数：
  3.0
• sp3杂化的碳原子比例：
  0.58
• 拓扑面积：
  158
• 氢给体数：
  2
• 氢受体数：
  9

反应信息

• 作为反应物：
  描述：

  N-(2-pentacosa-10,12-diynoylaminoethyl)-N-(N⁶-(benzyloxycarbonyl)adenin-9-ylacetyl)glycine methyl ester 在 lithium hydroxide 作用下， 以 四氢呋喃 、 水 为溶剂， 生成 N-(2-pentacosa-10,12-diynoylaminoethyl)-N-(N⁶-(benzyloxycarbonyl)adenin-9-ylacetyl)glycine
  参考文献：
  名称：

  Synthesis and polymerisation of lipophilic peptide nucleic acids derived from stearic acid and pentacosa-10,12-diynoic acid

  摘要：

  The adenine, cytosine and thymine peptide nucleic acid (PNA) monomers and PNA T-10 oligomers bearing either a diacetylenic or stearoyl moiety at the N- or C-terminus have been successfully prepared. The resulting thymine monomeric and T-10-mer derivatives have been subsequently incorporated into polydiacetylene-containing liposomes. (C) 2003 Elsevier Ltd. All rights reserved.

  DOI：

  10.1016/j.tetlet.2003.09.047
• 作为产物：
  描述：

  N-succinimidyl 10,12-pentacosadiynoic acid ester 在 O-(1H-benzotriazol-1-yl)-N,N,N',N'-tetramethyluronium hexafluorophosphate 、 N,N-二异丙基乙胺 作用下， 以 N,N-二甲基甲酰胺 为溶剂， 生成 N-(2-pentacosa-10,12-diynoylaminoethyl)-N-(N⁶-(benzyloxycarbonyl)adenin-9-ylacetyl)glycine methyl ester
  参考文献：
  名称：

  Synthesis and polymerisation of lipophilic peptide nucleic acids derived from stearic acid and pentacosa-10,12-diynoic acid

  摘要：

  The adenine, cytosine and thymine peptide nucleic acid (PNA) monomers and PNA T-10 oligomers bearing either a diacetylenic or stearoyl moiety at the N- or C-terminus have been successfully prepared. The resulting thymine monomeric and T-10-mer derivatives have been subsequently incorporated into polydiacetylene-containing liposomes. (C) 2003 Elsevier Ltd. All rights reserved.

  DOI：

  10.1016/j.tetlet.2003.09.047

文献信息

• Synthesis and polymerisation of lipophilic peptide nucleic acids derived from stearic acid and pentacosa-10,12-diynoic acid
  作者：Nicola M Howarth、W.Edward Lindsell、Euan Murray、Peter N Preston

  DOI：10.1016/j.tetlet.2003.09.047

  日期：2003.10

  The adenine, cytosine and thymine peptide nucleic acid (PNA) monomers and PNA T-10 oligomers bearing either a diacetylenic or stearoyl moiety at the N- or C-terminus have been successfully prepared. The resulting thymine monomeric and T-10-mer derivatives have been subsequently incorporated into polydiacetylene-containing liposomes. (C) 2003 Elsevier Ltd. All rights reserved.
• Lipophilic peptide nucleic acids containing a 1,3-diyne function: synthesis, characterization and production of derived polydiacetylene liposomes
  作者：Nicola M. Howarth、W. Edward Lindsell、Euan Murray、Peter N. Preston

  DOI：10.1016/j.tet.2005.07.021

  日期：2005.9

  Adenine-, cytosine- and thymine-containing peptide nucleic acid (PNA) monomers have been synthesized in which either diacetylenic or stearoyl moieties are attached to the N-or C-terminus; the diacetylenic group is embedded within a long hydrocarbon chain. A range of analogous lipophilic functionalized PNA oligomers have been prepared using either solid phase synthesis or a post-synthetic solution phase procedure following cleavage of the PNA oligomer from the solid Support. Selected functionalized PNA monomers and oligomers have been incorporated into liposomal polydiacetylenes and characterized by UV-vis absorption spectroscopy. Preliminary investigations show that blue PDA-liposomes containing thymine-based PNAs can be formed and that production of liposomes with other PNA systems are viable. (c) 2005 Elsevier Ltd. All rights reserved.