N-succinimidyl 10,12-pentacosadiynoic acid ester | 146064-06-4

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 吡咯烷类
• 英文名称: N-succinimidyl 10,12-pentacosadiynoic acid ester
• 英文别名: N-succinimidyl-10,12-pentacosadiynate；N-succinimidyl 10,12-pentacosadiynoate；2,5-Pyrrolidinedione, 1-[(1-oxo-10,12-pentacosadiynyl)oxy]-；(2,5-dioxopyrrolidin-1-yl) pentacosa-10,12-diynoate
• CAS: 146064-06-4
• 化学式: C₂₉H₄₅NO₄
• 分子量: 471.681
• InChiKey: JIGWVSFUKQIRJV-UHFFFAOYSA-N

物化性质

• 熔点：
  67 °C
• 沸点：
  589.7±52.0 °C(Predicted)
• 密度：
  1.03±0.1 g/cm3(Predicted)

计算性质

• 辛醇/水分配系数(LogP)：
  9.6
• 重原子数：
  34
• 可旋转键数：
  21
• 环数：
  1.0
• sp3杂化的碳原子比例：
  0.76
• 拓扑面积：
  63.7
• 氢给体数：
  0
• 氢受体数：
  4

反应信息

• 作为反应物：
  描述：

  N-succinimidyl 10,12-pentacosadiynoic acid ester 在 吡啶 作用下， 以 二氯甲烷 为溶剂， 生成 N,N-bis<<<<(13',15'-pentacosadiynamido-3,6-dioxaoctyl)carbamoyl>methyl>(carboxymethyl)amino>ethyl>glycine
  参考文献：
  名称：

  Paramagnetic Polymerized Liposomes: Synthesis, Characterization, and Applications for Magnetic Resonance Imaging

  摘要：

  Liposomes are biocompatible materials that show promise as vehicles for drug delivery, inhibitors of cell adhesion, and carriers for the introduction of genetic material into cells. In this paper, we describe the synthesis and characterization of a new class of polymerized liposome particles (paramagnetic polymerized liposome (PPL), Figure 1) that have lanthanide ion chelates as head groups and that can be easily visualized using magnetic resonance imaging (MRI). The R(1) molar relaxivity was found to depend primarily on the linker length (m) and on the surface metal density and only weakly on particle size. PPLs containing 10 mol % of compound 1b (m = 2) and 90 mol % of compound 3 had a R(1) = 12.2 mM(-1) s(-1), while PPLs with 10 mol % compound 1a (m = 1) and 90 mol % of compound 3 had a R(1) = 5.7 mM(-1) s(-1). PPLs with 10 mol % of compound 1a and 90 mol % of compound 4 had a R(1) = 8.9 mM(-1) s(-1), while PPLs with 50 mol % of compound 1a and 50 mol % of compound 4 had a R(1) = 4.3 mM(-1) s(-1). A biotinylated lipid (compound 2) was also incorporated into the particle without affecting R(1) relaxivities for use as a marker for histochemical studies. We have also for the first time used atomic force microscopy (AFM) to investigate the size and nature of these particles in an aqueous environment. We feel that these new materials may prove useful for the in vivo investigation of liposome formulations as vehicles for therapeutic applications and for evaluating tissue pathology with MRI.

  DOI：

  10.1021/ja00133a001
• 作为产物：
  描述：

  10,12-二十五碳二炔酸 在 N-羟基丁二酰亚胺 、 盐酸-N-乙基-Nˊ-(3-二甲氨基丙基)碳二亚胺 作用下， 以 二氯甲烷 为溶剂， 反应 12.0h， 生成 N-succinimidyl 10,12-pentacosadiynoic acid ester
  参考文献：
  名称：

  量身定制的聚二乙炔胶束，用于催化水中的1,3-偶极环加成反应

  摘要：

  通过在聚二乙炔胶束中络合氯化铜来开发胶体催化剂。通过提供合适的配体环境，将后者设计为容纳和稳定铜盐。胶束因其中心疏水核而不仅可以在水中分散，还可以在催化剂附近浓缩试剂，因此被誉为纳米反应器，可以促进水中的惠斯根环加成反应。发现该系统可在多种基材上运行并在可持续条件下有效运行。

  DOI：

  10.1002/adsc.202000795

文献信息

• Selective conversion of nitroarenes using a carbon nanotube–ruthenium nanohybrid
  作者：Dhanaji V. Jawale、Edmond Gravel、Caroline Boudet、Nimesh Shah、Valérie Geertsen、Haiyan Li、Irishi N. N. Namboothiri、Eric Doris

  DOI：10.1039/c4cc09192b

  日期：——

  Ruthenium nanoparticles were assembled on carbon nanotubes and the resulting nanohybrid was used in the hydrazine-mediated catalytic hydrogenation of various nitroarenes, at room temperature.

  ruthenium纳米颗粒被组装在碳纳米管上，所得到的纳米杂化材料被用于室温下肼介导的催化氢化各种硝基芳烃。
• Targeted multivalent macromolecules
  申请人：TARGESOME, INC.

  公开号：US20030129223A1

  公开（公告）日：2003-07-10

  Targeted therapeutic agents, comprising a linking carrier, a therapeutic entity associated with the linking carrier, and at least one targeting entity are provided, as well as methods for their preparation and use.

  靶向治疗剂，包括一个连接载体，与连接载体相关联的治疗实体，以及至少一个靶向实体，以及它们的制备和使用方法。
• Catalytic Oxidation of Silanes by Carbon Nanotube-Gold Nanohybrids
  作者：Jubi John、Edmond Gravel、Agnès Hagège、Haiyan Li、Thierry Gacoin、Eric Doris

  DOI：10.1002/anie.201101993

  日期：2011.8.8

  Turning over silanes: The first nanotube‐based catalytic system for silane oxidation is reported (see scheme). The reusable gold–nanotube hybrid cleanly oxidizes both alkyl and aryl silanes in high yields, under mild reaction conditions, and compares most favorably to any other catalytic system in terms of overall efficacy and turnover values.

  上交硅烷：报道了首个用于硅烷氧化的基于纳米管的催化体系（参见方案）。可重复使用的金纳米管杂化剂在温和的反应条件下可以高收率干净地氧化烷基硅烷和芳基硅烷，并且在整体功效和周转率方面，与任何其他催化体系相比，都是最有利的。
• 열적 특성이 개선된 도펀트 제조방법 및 이에 따라 제조된 도펀트를 포함하는 전도성 나노 복합체
  申请人：LOTTE CHEMICAL CORPORATION 롯데케미칼 주식회사(119980046011) Corp. No ▼ 110111-0193196BRN ▼118-81-15012

  公开号：KR20190064339A

  公开（公告）日：2019-06-10

  본 발명은 열적 특성이 개선된 도펀트 제조방법 및 이에 따라 제조된 도펀트를 포함하는 전도성 나노 복합체에 관한 것으로, 보다 상세하게는 폴리아닐린에 도핑하여 우수한 전기전도성 및 열적 특성을 나타내는 도펀트 제조방법 및 이에 따라 제조된 도펀트 및 폴리아닐린을 포함하는 전도성 나노 복합체에 관한 것이다. 본 발명에서는 도펀트의 열적안정성을 개선하기 위해 다이아세틸렌 유도체의 한쪽 말단기를 술폰산(sulfonic acid) 또는 벤젠술폰산(Benzenesulfnoic acid)으로 치환하여 술폰산 그룹에 의해 우수한 도핑 특성을 가지며 증가된 아로마틱(Aromatic), 알리파틱(Aliphatic) 그룹으로 인하여 열적안정성이 증가된 도펀트를 우수한 수율로 제조할 수 있는 방법을 제공할 수 있다.

  本发明涉及一种改进热特性的聚合物制备方法以及由此制备的包含聚合物的导电纳米复合材料，更详细地说，涉及一种通过在聚苯胺中掺杂以表现出优异的电导性和热特性的聚合物制备方法，以及由此制备的聚合物和聚苯胺组成的导电纳米复合材料。本发明提供了一种能够以优秀的产率制备出热稳定性改善的聚合物的方法，其中通过将二乙酰乙烯诱导体的一端基取代为磺酸(sulfonic acid)或苯基磺酸(Benzenesulfonic acid)，通过磺酸基团具有优异的掺杂特性，并且由于增加了芳香族(Aromatic)、脂肪族(Aliphatic)基团，可以提高热稳定性。
• Synthesis of 1,3-Diynes in the Purine, Pyrimidine, 1,3,5-Triazine and Acridine Series
  作者：W. Edward Lindsell、Christopher Murray、Peter N. Preston、Thomas A.J. Woodman

  DOI：10.1016/s0040-4020(00)00016-8

  日期：2000.2

  groups as terminal heterocyclic substituents in both R1 and R2 are bonded through methylene linkers (CH2)n, n=1, 4 or 9} to the 1,3-diyne; also reported are amphiphilic species with R2=n-C10H21 and a single heteroaromatic head group in chain R1. Compounds in the acridine series are also amphiphiles and contain quaternised 1′-(9-acridinylamino)- and 1′-(6-chloro-2-methoxyacridinylamino)- terminal substituents

  一系列共轭的1,3-二炔的，R 1 CCCCR 2，已准备了包含以下的杂芳族单元作为取代基的头部基团R 1和/或R 2：嘧啶基，嘌呤基，2,4-二氨基-1,3,5-三嗪基和a啶基。在R 1和R 2中均含有前三个基团作为末端杂环取代基的化合物通过亚甲基接头（CH 2）n，n = 1、4或9}键合至1,3-二炔；还报道了R 2 = n -C 10 H 21的两亲物种和在链R 1中的单个杂芳族头基。cr啶系列中的化合物也是两亲性的，并包含季铵化的1'-（9-ac啶基氨基）-和1'-（6-氯-2-甲氧基ac啶基氨基）-通过PEG和亚甲基单元连接至二炔功能的末端取代基。新的二炔是通过相应的ω-杂芳族官能化的1-炔的氧化偶合或通过预先形成的二炔上末端基团的转化而合成的。