2-deoxy-2-iodo-3,4,6-tri-O-acetyl-1-O-triethylsilyl-β-D-glucopyranose | 1071185-08-4

• 分子结构分类: 有机化合物 - 有机氧化合物
• 英文名称: 2-deoxy-2-iodo-3,4,6-tri-O-acetyl-1-O-triethylsilyl-β-D-glucopyranose
• 英文别名: 2-Deoxy-2-iodo-3,4,6-tri-O-acetyl-1-O-triethylsilyl-beta-D-glucopyranose；[(2R,3R,4S,5R,6S)-3,4-diacetyloxy-5-iodo-6-triethylsilyloxyoxan-2-yl]methyl acetate
• CAS: 1071185-08-4
• 化学式: C₁₈H₃₁IO₈Si
• 分子量: 530.429
• InChiKey: MOTCUJUTPQFGEE-ZKXLYKBJSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  2.96
• 重原子数：
  28
• 可旋转键数：
  12
• 环数：
  1.0
• sp3杂化的碳原子比例：
  0.83
• 拓扑面积：
  97.4
• 氢给体数：
  0
• 氢受体数：
  8

反应信息

• 作为反应物：
  描述：

  2-deoxy-2-iodo-3,4,6-tri-O-acetyl-1-O-triethylsilyl-β-D-glucopyranose 在 甲醇 、 potassium carbonate 作用下， 以 氯仿 为溶剂， 以20%的产率得到2-deoxy-2-iodo-1-O-triethylsilyl-β-D-glucopyranose
  参考文献：
  名称：

  WO2008/131024

  摘要：

  公开号：
• 作为产物：
  描述：

  三乙基氯硅烷 、 3,4,6-tri-O-acetyl-2-deoxy-2-iodo-D-mannose 、 2-deoxy-2-iodo-(3,4,6)-tri-O-acetyl-D-glucopyranose 在 咪唑 作用下， 以 二氯甲烷 为溶剂， 以5%的产率得到2-deoxy-2-iodo-3,4,6-tri-O-acetyl-1-O-triethylsilyl-β-D-glucopyranose
  参考文献：
  名称：

  WO2008/131024

  摘要：

  公开号：

文献信息

• Iodo-hexose compounds useful to treat cancer
  申请人：Board of Regents, The University of Texas System

  公开号：US08299033B2

  公开（公告）日：2012-10-30

  Methods of treating glioblastoma and pancreatic cancer are provided by the administration of a therapeutically effective amount of a iodo-hexose compound to a subject in need thereof. The subject disclosure includes methods of treating glioblastoma and pancreatic cancer comprising the administration of a therapeutically effective amount of a 2-deoxy-2-iodo-D-hexose compound including 2-deoxy-2-iodo-D-mannose, 2-deoxy-2-iodo-D-glucose, 2-deoxy-2-iodo-D-galactose, and/or 2-deoxy-2-iodo-D-talose to a subject in need thereof.

  本发明提供了一种通过向需要治疗的受体中注射治疗有效量的碘代己糖化合物来治疗胶质母细胞瘤和胰腺癌的方法。该主题披露了一种治疗胶质母细胞瘤和胰腺癌的方法，包括向需要治疗的受体中注射治疗有效量的2-去氧-2-碘-D-己糖化合物，包括2-去氧-2-碘-D-甘露糖，2-去氧-2-碘-D-葡萄糖，2-去氧-2-碘-D-半乳糖和/或2-去氧-2-碘-D-赖糖。
• Iodo-Hexose Compounds Useful to Treat Cancer
  申请人：Priebe Waldemar

  公开号：US20100152121A1

  公开（公告）日：2010-06-17

  Methods of treating glioblastoma and pancreatic cancer are provided by the administration of a therapeutically effective amount of a iodo-hexose compound to a subject in need thereof. The subject disclosure includes methods of treating glioblastoma and pancreatic cancer comprising the administration of a therapeutically effective amount of a 2-deoxy-2-iodo-D-hexose compound including 2-deoxy-2-iodo-D-mannose, 2-deoxy-2-iodo-D-glucose, 2-deoxy-2-iodo-D-galactose, and/or 2-deoxy-2-iodo-D-talose to a subject in need thereof.

  本发明提供了治疗胶质母细胞瘤和胰腺癌的方法，通过向需要治疗的受试者施用治疗有效量的碘代己糖化合物。该主题公开包括治疗胶质母细胞瘤和胰腺癌的方法，包括向需要治疗的受试者施用治疗有效量的2-脱氧-2-碘-D-己糖化合物，包括2-脱氧-2-碘-D-甘露糖、2-脱氧-2-碘-D-葡萄糖、2-脱氧-2-碘-D-半乳糖和/或2-脱氧-2-碘-D-他糖。