OFL-TBBQ | 1106701-58-9

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 喹啉及其衍生物
• 英文名称: OFL-TBBQ
• CAS: 1106701-58-9
• 化学式: C₆Br₄O₂*C₁₈H₂₀FN₃O₄
• 分子量: 785.054
• InChiKey: MGVYIIABBKYRGK-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  4.69
• 重原子数：
  38.0
• 可旋转键数：
  2.0
• 环数：
  5.0
• sp3杂化的碳原子比例：
  0.33
• 拓扑面积：
  109.15
• 氢给体数：
  1.0
• 氢受体数：
  8.0

反应信息

• 作为产物：
  描述：

  四溴对苯醌 、 氧氟沙星 以 甲醇 为溶剂， 反应 0.5h， 生成 OFL-TBBQ
  参考文献：
  名称：

  Study of fluorescence characteristics of the charge-transfer reaction of quinolone agents with bromanil

  摘要：

  A spectrofluorimetric method was discussed for the determination of three antibacterial quinolone derivatives, ofloxacin (OFL), norfloxacin (NOR) and ciprofloxacin (CIP) through charge-transfer complexation (CTC) with 2,3.5,6-tetrabromo-1,4-benzoquinone (bromanil, TBBQ). The method was based on the reaction of these drugs as n-electron donors with the pi-acceptor TBBQ. TBBQ was found to react with these drugs to produce a kind of yellow complexes and the fluorescence intensities of the complexes were enhanced by 29-36 times more than those of the corresponding monomers. UV-vis, H-1 NMR and XPS techniques were used to study the complexes formed. The various experimental parameters affecting the fluorescence intensity were studied and optimized. Under optimal reaction conditions, the rectilinear calibration graphs were obtained in the concentration range of 0.021-2.42 mu g mL(-1), 0.017-2.63 mu g mL(-1) and 0.019-2.14 mu g mL(-1) for OFL, NOR and CIP, respectively. The methods developed were applied successfully to the determination of the subject drugs in their pharmaceutical dosage forms with good precision and accuracy compared to official and reported methods as revealed by t- and F-tests. (c) 2008 Elsevier B.V. All rights reserved.

  DOI：

  10.1016/j.saa.2008.06.045