2-(aminomethyl)-1-benzoyl-1,2,3,4-tetrahydro-7-(trifluoromethyl)quinoline hydrochloride | 96430-17-0

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 喹啉及其衍生物
• 英文名称: 2-(aminomethyl)-1-benzoyl-1,2,3,4-tetrahydro-7-(trifluoromethyl)quinoline hydrochloride
• CAS: 96430-17-0
• 化学式: C₁₈H₁₇F₃N₂O*ClH
• 分子量: 370.802
• InChiKey: HITLNPBLUGDMCP-UHFFFAOYSA-N

反应信息

• 作为反应物：
  描述：

  2-(aminomethyl)-1-benzoyl-1,2,3,4-tetrahydro-7-(trifluoromethyl)quinoline hydrochloride 在 盐酸 作用下， 以 乙醇 为溶剂， 反应 18.0h， 以47%的产率得到2-(aminomethyl)-1,2,3,4-tetrahydro-7-(trifluoromethyl)quinoline
  参考文献：
  名称：

  Bioactive conformation of 1-arylpiperazines at central serotonin receptors

  摘要：

  A number of 1-arylpiperazines have been characterized as direct-acting serotonin agonists. Conformational parameters of this class that may affect receptor recognition and binding have been examined through the analysis of X-ray data and synthesis of rigid analogues. Radioligand binding studies indicate that 2,3,4,4a,5,6-hexahydro-9-(trifluoromethyl)-1H-pyrazino[1,2-a]quinoline, an arylpiperazine that mimics the X-ray conformation of the serotonin agonist 1-(6-chloropyrazin-2-yl)piperazine, exhibits high affinity for serotonin receptors, suggesting that the two rings of 1-arylpiperazines are relatively coplanar in the bioactive conformation.

  DOI：

  10.1021/jm00145a017