4-Hydroxy-1,7-dioxaspiro<5.5>undecane | 83015-80-9

• 分子结构分类: 有机化合物 - 有机氧化合物
• 英文名称: 4-Hydroxy-1,7-dioxaspiro<5.5>undecane
• 英文别名: 1,7-dioxaspiro[5.5]undecan-4-ol
• CAS: 83015-80-9
• 化学式: C₉H₁₆O₃
• 分子量: 172.224
• InChiKey: ITVCIGAVUFJFJY-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  0.6
• 重原子数：
  12
• 可旋转键数：
  0
• 环数：
  2.0
• sp3杂化的碳原子比例：
  1.0
• 拓扑面积：
  38.7
• 氢给体数：
  1
• 氢受体数：
  3

反应信息

• 作为产物：
  描述：

  2-[(E)-4-(Tetrahydro-pyran-2-yloxy)-but-1-enyl]-tetrahydro-pyran-2-ol 在 盐酸 作用下， 以 四氢呋喃 、 水 为溶剂， 反应 24.0h， 生成 4-Hydroxy-1,7-dioxaspiro<5.5>undecane
  参考文献：
  名称：

  橄榄蝇（Dacus oleae）中3-和4-羟基-1,7-二氧杂螺[5.5]十一烷的分离与合成

  摘要：

  从雌性橄榄蝇（Dacus oleae）的直肠腺体中分离出两个新颖的羟基螺缩醛3-和4-羟基-1,7-二氧杂螺[5.5]十一烷，并开发了后者的立体选择性合成方法。

  DOI：

  10.1039/c39820000601

文献信息

• Alkylation reactions of anions derived from 2-benzenesulphonyl tetrahydropyran and their application to spiroketal syntiesis
  作者：Steven V. Ley、Barry Lygo、Francine Sternfeld、Anne Wonnacott

  DOI：10.1016/s0040-4020(01)87660-2

  日期：1986.1

  Deprotonation of (1) follwed by alkylation with carbonyl compounds or halides gave cyclic enol ether addition products by spontaneous elimination of benzenesulphinic acid. Interception of the initial addition products with aldehydes by reductive desulphonylation to give alkylated tetrahydropyran derivatives proeeeded in moderate yield using sodium naphthalenide. Several of the cystic enol ether addition products

  3,4-二氢-2H-吡喃或2-甲氧基四氢吡喃与苯磺酸反应生成2-苯磺酰基四氢吡喃（1）。（1）通过与羰基化合物或卤化物进行烷基化反应进行脱质子化，通过自发消除生成环状烯醇醚加成产物苯磺酸。通过萘二甲磺酸钠的还原性去磺酰化作用，将起始的加成产物与醛类截获，以得到中等收率的烷基化四氢吡喃衍生物。几个囊性烯醇醚加成产物进一步转化成spiroketals包括来自天然产物的信息素的合成和。
• SLOW-RELEASE FORMULATION CONTAINING GEL COMPOSITION FOR USE ON PESTS
  申请人：Shin-Etsu Chemical Co., Ltd.

  公开号：EP2805615A1

  公开（公告）日：2014-11-26

  Provided is a sustained release preparation comprising an insect pest-targeting gel composition, the preparation being free from leakage or reaction of a volatile substance and being capable of releasing the volatile substance at a constant rate. More specifically, provided is a sustained release preparation comprising a polymer tube and an insect pest-targeting gel composition in the polymer tube, the composition comprising one or more volatile substances and an oil gelling agent, wherein the volatile substances are comprised in an amount of from 70.0 to 99.0% by weight by the insect pest-targeting composition and are released outside of the polymer tube through the polymer tube.

  本发明提供了一种包含害虫靶向凝胶组合物的缓释制剂，该制剂中的挥发性物质不会泄漏或发生反应，并且能够以恒定的速率释放挥发性物质。更具体地说，本发明提供了一种持续释放制剂，包括聚合物管和聚合物管中的害虫靶向凝胶组合物，该组合物包括一种或多种挥发性物质和油胶凝剂，其中挥发性物质的含量为害虫靶向组合物重量的 70.0% 至 99.0%，并通过聚合物管释放到聚合物管外。
• Insect pest-targeting gel composition and sustained release preparation comprising that
  申请人：SHIN-ETSU CHEMICAL CO., LTD.

  公开号：US10244750B2

  公开（公告）日：2019-04-02

  Provided are an insect pest-targeting gel composition causing neither leakage nor reaction of a volatile substance and capable of releasing the volatile substance at a constant rate; and a sustained release preparation including the insect pest-targeting gel composition. More specifically, provided is an insect pest-targeting gel composition including one or more volatile substances and an oil gelling agent, wherein the volatile substance is included in an amount of from 70.0 to 99.0% by weight by the insect pest-targeting gel composition.

  本发明提供了一种害虫靶向凝胶组合物，该组合物不会导致挥发性物质泄漏或反应，并能以恒定速率释放挥发性物质；还提供了一种包含该害虫靶向凝胶组合物的缓释制剂。更具体地说，提供了一种包含一种或多种挥发性物质和油胶凝剂的害虫靶向凝胶组合物，其中挥发性物质的含量为害虫靶向凝胶组合物重量的 70.0% 至 99.0%。
• Synthetically useful dianions via reductive lithiation of tetrahydrofurans by aromatic radical anions
  作者：Boguslaw Mudryk、Theodore Cohen

  DOI：10.1021/ja00005a080

  日期：1991.2
• [¹⁸O]-Oxygen Incorporation Reveals Novel Pathways in Spiroacetal Biosynthesis by <i>Bactrocera cacuminata</i> and <i>B. cucumis</i>
  作者：Mary T. Fletcher、Barry J. Wood、Ian M. Brereton、Jeanette E. Stok、James J. De Voss、William Kitching

  DOI：10.1021/ja026215l

  日期：2002.7.1

  The origins of the oxygen atoms in 1,7-dioxaspiro[5.5]undecane (1) and hydroxyspiroacetal (2) from Bactrocera cacuminata, and in 2,8-dimethyl-1,7-dioxaspiro[5.5]undecane (3) and hydroxyspiroacetal (4) from B. cucumis, have been investigated by incorporation studies from both [(18)O(2)]-dioxygen and [(18)O]-water. Combined GC-MS examination and high-field NMR analysis have demonstrated that all oxygen atoms in 1 and 2 from B. cacuminata are dioxygen derived, but in contrast, the spiroacetals 3 and 4 from B. cucumis incorporate one ring oxygen from water and one ring oxygen (and the hydroxyl oxygen in 4) from [(18)O(2)]-dioxygen. These results reveal not only the generality of monoxygenase mediation of spiroacetal formation in Bactrocera sp., but also an unexpected complexity in their biosynthesis. A general paradigm accommodating these and other observations is presented.