| 1388841-34-6

• 分子结构分类: 有机化合物 - 有机氧化合物
• CAS: 1388841-34-6
• 化学式: C₄₇H₇₂O₇
• 分子量: 749.084
• InChiKey: ICXVDIURCHTBIX-OWBHPGMISA-N

反应信息

• 作为反应物：
  描述：

  在 二甲基硫 、 臭氧 作用下， 以 二氯甲烷 为溶剂， 反应 6.0h， 生成
  参考文献：
  名称：

  Alkenylresorcinols and cytotoxic activity of the constituents isolated from Labisia pumila

  摘要：

  Phytochemical investigation on the leaves of Labisia pumila (Myrsinaceae), an important medicinal herb in Malaysia, has led to the isolation of 1-O-methyl-6-acetoxy-5-(pentadec-10Z-enyl)resorcinol (1), labisiaquinone A (2) and labisiaquinone B (3). Along with these, 16 known compounds including 1-O-methyl-6-acetoxy-5-pentadecylresorcinol (4), 5-(pentadec-10Z-enyl)resorcinol (5), 5-(pentadecyl)resorcinol (6), (-)-loliolide (7), stigmasterol (8), 4-hydroxyphenylethylamine (9), 3,4,5-trihydroxybenzoic acid (10), 3,4-dihydroxybenzoic acid (11), (+)-catechin (12), (-)-epicatechin (13), kaempferol-3-O-alpha-rhamnopyranosyl-7-O-beta-glycopyranoside (14), kaempferol-4'-O-beta-glycopyranoside (15), quercetin-3-O-alpha-rhamnopyranoside (16), kaempferol-3-O-alpha-rhamnopyranoside (17), (9Z,12Z)-octadeca-9,12-dienoic acid (18) and stigmasterol-3-O-beta-glycopyranoside (19) were also isolated. The structures of these compounds were established on the basis of 1D and 2D NMR spectroscopy techniques (H-1, C-13, COSY, HSQC, NOESY and HMBC experiments), mass spectrometry and chemical derivatization. Among the constituents tested 1 and 4 exhibited strongest cytotoxic activity against the PC3, HCT116 and MCF-7 cell lines (IC50 values <= 10 mu M), and they showed selectivity towards the first two-cell lines relative to the last one. (C) 2012 Elsevier Ltd. All rights reserved.

  DOI：

  10.1016/j.phytochem.2012.04.008
• 作为产物：
  描述：

  labisiaquinone B 、 乙酸酐 在 吡啶 作用下， 反应 12.0h， 生成
  参考文献：
  名称：

  Alkenylresorcinols and cytotoxic activity of the constituents isolated from Labisia pumila

  摘要：

  Phytochemical investigation on the leaves of Labisia pumila (Myrsinaceae), an important medicinal herb in Malaysia, has led to the isolation of 1-O-methyl-6-acetoxy-5-(pentadec-10Z-enyl)resorcinol (1), labisiaquinone A (2) and labisiaquinone B (3). Along with these, 16 known compounds including 1-O-methyl-6-acetoxy-5-pentadecylresorcinol (4), 5-(pentadec-10Z-enyl)resorcinol (5), 5-(pentadecyl)resorcinol (6), (-)-loliolide (7), stigmasterol (8), 4-hydroxyphenylethylamine (9), 3,4,5-trihydroxybenzoic acid (10), 3,4-dihydroxybenzoic acid (11), (+)-catechin (12), (-)-epicatechin (13), kaempferol-3-O-alpha-rhamnopyranosyl-7-O-beta-glycopyranoside (14), kaempferol-4'-O-beta-glycopyranoside (15), quercetin-3-O-alpha-rhamnopyranoside (16), kaempferol-3-O-alpha-rhamnopyranoside (17), (9Z,12Z)-octadeca-9,12-dienoic acid (18) and stigmasterol-3-O-beta-glycopyranoside (19) were also isolated. The structures of these compounds were established on the basis of 1D and 2D NMR spectroscopy techniques (H-1, C-13, COSY, HSQC, NOESY and HMBC experiments), mass spectrometry and chemical derivatization. Among the constituents tested 1 and 4 exhibited strongest cytotoxic activity against the PC3, HCT116 and MCF-7 cell lines (IC50 values <= 10 mu M), and they showed selectivity towards the first two-cell lines relative to the last one. (C) 2012 Elsevier Ltd. All rights reserved.

  DOI：

  10.1016/j.phytochem.2012.04.008