4-(4-aminobenzoyl)-2-(2,4-dimethoxybenzyl)-7-(1-(phenylsulfonyl)-1H-pyrrolo[2,3-b]pyridin-3-yl)pyrrolo[1,2-a]pyrazin-1(2H)-one | 1338811-45-2

• 分子结构分类: 有机化合物 - 有机氧化合物
• 英文名称: 4-(4-aminobenzoyl)-2-(2,4-dimethoxybenzyl)-7-(1-(phenylsulfonyl)-1H-pyrrolo[2,3-b]pyridin-3-yl)pyrrolo[1,2-a]pyrazin-1(2H)-one
• 英文别名: 4-(4-Aminobenzoyl)-7-[1-(benzenesulfonyl)pyrrolo[2,3-b]pyridin-3-yl]-2-[(2,4-dimethoxyphenyl)methyl]pyrrolo[1,2-a]pyrazin-1-one
• CAS: 1338811-45-2
• 化学式: C₃₆H₂₉N₅O₆S
• 分子量: 659.722
• InChiKey: FAYFOFKXNUXMTC-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  4.8
• 重原子数：
  48
• 可旋转键数：
  9
• 环数：
  7.0
• sp3杂化的碳原子比例：
  0.08
• 拓扑面积：
  147
• 氢给体数：
  1
• 氢受体数：
  8

文献信息

• PYRROLOPYRAZINONE INHIBITORS OF KINASES
  申请人：Zhu Gui-Dong

  公开号：US20110257189A1

  公开（公告）日：2011-10-20

  The present invention relates to compounds of formula (I) or pharmaceutical acceptable salts, wherein R 1a , R 1b , R 1c , X, Y, Z, n, and m are defined in the description. The present invention relates also to compositions containing said compounds which are useful for inhibiting kinases such as Cdc7 and methods of treating diseases such as cancer.

  本发明涉及化合物的结构式(I)或其药用可接受的盐，其中R1a、R1b、R1c、X、Y、Z、n和m如描述中所定义。本发明还涉及含有上述化合物的组合物，用于抑制Cdc7等激酶，以及治疗癌症等疾病的方法。
• US8450320B2
  申请人：——

  公开号：US8450320B2

  公开（公告）日：2013-05-28
• [EN] PYRROLOPYRAZINONE INHIBITORS OF KINASES<br/>[FR] INHIBITEURS DE KINASES DE TYPE PYRROLOPYRAZINONE
  申请人：ABBOTT LAB

  公开号：WO2011130481A1

  公开（公告）日：2011-10-20

  The present invention relates to compounds of formula (I) or pharmaceutical acceptable salts, (Formula (I)) wherein R1a, R1b, R1c, X, Y, Z, n, and m are defined in the description. The present invention relates also to compositions containing said compounds which are useful for inhibiting kinases such as Cdc7 and methods of treating diseases such as cancer.