1,4-bis-(4-bromo-phenyl)-2-methoxy-butane-1,4-dione | 173420-64-9

• 分子结构分类: 有机化合物 - 木脂素、新木脂素和相关化合物
• 英文名称: 1,4-bis-(4-bromo-phenyl)-2-methoxy-butane-1,4-dione
• 英文别名: 1,4-Bis-(4-brom-phenyl)-2-methoxy-butan-1,4-dion；1,2-Bis(4-bromobenzoyl)-1-methoxyethane；1,4-bis(4-bromophenyl)-2-methoxybutane-1,4-dione
• CAS: 173420-64-9
• 化学式: C₁₇H₁₄Br₂O₃
• 分子量: 426.104
• InChiKey: MAVSTRAZYGRNAK-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  4.2
• 重原子数：
  22
• 可旋转键数：
  6
• 环数：
  2.0
• sp3杂化的碳原子比例：
  0.18
• 拓扑面积：
  43.4
• 氢给体数：
  0
• 氢受体数：
  3

反应信息

• 作为反应物：
  描述：

  1,4-bis-(4-bromo-phenyl)-2-methoxy-butane-1,4-dione 生成 甲醇 、 alkaline earth salt of/the/ methylsulfuric acid
  参考文献：
  名称：

  Lutz, Journal of the American Chemical Society, 1929, vol. 51, p. 3020

  摘要：

  DOI：
• 作为产物：
  描述：

  (E)-1,4-bis(4-bromophenyl)but-2-ene-1,4-dione 在 /BRN= 3592982/ 作用下， 以 甲醇 为溶剂， 生成 1,4-bis-(4-bromo-phenyl)-2-methoxy-butane-1,4-dione
  参考文献：
  名称：

  The Base-catalyzed Addition of Methanol to Dibenzoylethylenes

  摘要：

  DOI：

  10.1021/ja00887a016

文献信息

• Methods of inhibiting Pneumocystis carinii pneumonia, Giardia lamblia,
  申请人：The University of North Carolina at Chapel Hill

  公开号：US05602172A1

  公开（公告）日：1997-02-11

  The present invention provides methods for treating Pneumocystis carinii pneumonia, Giardia lamblia, and Cryptosporidium parvum in a subject in need of such treatment. The methods comprise adminstering to the subject a compound of Formula (I): ##STR1## wherein: R.sub.1 and R.sub.2 are each independently selected from the group consisting of H, loweralkyl, aryl, alkylaryl, aminoalkyl, aminoaryl, halogen, oxyalkyl, oxyaryl, or oxyarylalkyl; R.sub.3 and R.sub.4 are each independently selected from the group consisting of H, loweralkyl, oxyalkyl, alkylaryl, aryl, oxyaryl, aminoalkyl, aminoaryl, or halogen; and X and Y are located in the para or meta positions and are selected from the group consisting of H, loweralkyl, oxyalkyl, and ##STR2## wherein: each R.sub.5 is independently selected from the group consisting of H, loweralkyl, alkoxyalkyl, hydroxyalkyl, aminoalkyl, alkylaminoalkyl, cycloalkyl, aryl, or alkylaryl or two R.sub.5 groups together represent C.sub.2 -C.sub.10 alkyl, hydroxyalkyl, or alkylene; and R.sub.6 is H, hydroxy, loweralkyl, alkoxyalkyl, hydroxyalkyl, aminoalkyl, alkylamino, alkylaminoalkyl, cycloalkyl, hydroxycycloalkyl, alkoxycycloalkyl, aryl, or alkylaryl; or a phamaceutically acceptable salt thereof. The compounds ar administered in an amount effective to treat the condition. The present invention also includes novel compounds useful in the treatment of Pneumocystis carinii pneumonia, Giardia lamblia, and Cryptosporidium parvum.

  本发明提供了一种治疗需要此类治疗的主体的肺孢子菌性肺炎、贾第鞭毛虫和小隐孢子虫的方法。该方法包括向该主体施用式（I）的化合物：##STR1## 其中：R.sub.1和R.sub.2各自独立地选自H、较低烷基、芳基、烷基芳基、氨基烷基、氨基芳基、卤素、氧烷基、氧基芳基或氧基芳基烷基的群；R.sub.3和R.sub.4各自独立地选自H、较低烷基、氧烷基、烷基芳基、芳基、氧基芳基、氨基烷基、氨基芳基或卤素的群；X和Y位于对位或间位，并选自H、较低烷基、氧烷基和##STR2## 其中：每个R.sub.5独立地选自H、较低烷基、烷氧基烷基、羟基烷基、氨基烷基、烷基氨基烷基、环烷基、芳基或烷基芳基，或两个R.sub.5基团共同表示C.sub.2-C.sub.10烷基、羟基烷基或烷基烷基；R.sub.6是H、羟基、较低烷基、烷氧基烷基、羟基烷基、氨基烷基、烷基氨基、烷基氨基烷基、环烷基、羟基环烷基、烷氧基环烷基、芳基或烷基芳基；或其药学上可接受的盐。该化合物的剂量有效地治疗该状态。本发明还包括在肺孢子菌性肺炎、贾第鞭毛虫和小隐孢子虫的治疗中有用的新化合物。
• Method of fluorescent detection of nucleic acids and cytoskeleton
  申请人：Georgia State University Research Foundation

  公开号：US05594138A1

  公开（公告）日：1997-01-14

  Disclosed is a method of fluorescent detection of a nucleic acid. The method comprises contacting to the nucleic acid a bis-dicationic aryl furan compound, such as 2,5-bis[4-(4,5,6,7-tetrahydro-1H-1,3-diazepin-2-yl) phenyl] furan; 2,5-bis[4-(N-isopropyl) amidino] phenyl}furan; and physiologically acceptable salts thereof, and exposing the nucleic acid to light at a frequency to induce fluorescence of the compound. A method for fluorescent detection of cytoskeleton elements, and novel bis-dicationic aryl furan compounds are also disclosed.

  本发明公开了一种核酸荧光检测方法。该方法包括将双二阳离子芳基呋喃化合物（例如2,5-双[4-(4,5,6,7-四氢-1H-1,3-二氮杂环-2-基)苯基]呋喃；2,5-双[4-(N-异丙基)氨基甲酰基]苯基}呋喃；以及其生理上可接受的盐）与核酸接触，并将核酸暴露于诱导化合物荧光的光频下。本发明还公开了一种细胞骨架元素荧光检测方法和新型的双二阳离子芳基呋喃化合物。
• FURAN DERIVATIVES FOR INHIBITING PNEUMOCYSTIS CARINII PNEUMONIA, GIARDIA LAMBLIA AND CRYPTOSPORIDIUM PARVUM
  申请人：GEORGIA STATE UNIVERSITY RESEARCH FOUNDATION, INC.

  公开号：EP0792271B1

  公开（公告）日：2002-02-27
• US5602172A
  申请人：——

  公开号：US5602172A

  公开（公告）日：1997-02-11
• US5594138A
  申请人：——

  公开号：US5594138A

  公开（公告）日：1997-01-14