5-(4-methoxyphenyl)-7-(pyridin-3-yl)-5H-thiazolo[3,2-a]pyrimidin-3(2H)-one | 1023286-77-2

• 分子结构分类: 有机化合物 - 苯类化合物 - 苯酚醚
• 英文名称: 5-(4-methoxyphenyl)-7-(pyridin-3-yl)-5H-thiazolo[3,2-a]pyrimidin-3(2H)-one
• CAS: 1023286-77-2
• 化学式: C₁₈H₁₅N₃O₂S
• 分子量: 337.402
• InChiKey: LIZYRJKWPKUQIS-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  3.12
• 重原子数：
  24.0
• 可旋转键数：
  3.0
• 环数：
  4.0
• sp3杂化的碳原子比例：
  0.17
• 拓扑面积：
  54.79
• 氢给体数：
  0.0
• 氢受体数：
  5.0

反应信息

• 作为反应物：
  描述：

  5-(4-methoxyphenyl)-7-(pyridin-3-yl)-5H-thiazolo[3,2-a]pyrimidin-3(2H)-one 、 3-吲哚甲醛 以 乙酸酐 、 溶剂黄146 为溶剂， 反应 5.0h， 以72%的产率得到2-(1H-indol-3-ylmethylidene)-5-(4-methoxyphenyl)-7-pyridin-3-yl-5H-[1,3]thiazolo[3,2-a]pyrimidin-3-one
  参考文献：
  名称：

  Synthesis, Analgesic, and Antiparkinsonian Profiles of Some Pyridine, Pyrazoline, and Thiopyrimidine Derivatives

  摘要：

  A series of substituted pyridine, pyrazoline, and thiopyrimidine derivatives were synthesized from 3-acetylpyridine, which was prepared from nicotinic acid as a naturally starting material. The pharmacological screening showed that many of these compounds have good analgesic and antiparkinsonian activities comparable to Voltarene (R) and Benzatropine (R) as reference drugs. The structure assignment of the new compounds is based on chemical and spectroscopic evidence. The detailed synthesis, spectroscopic data, and pharmacological properties for synthesized compounds are reported.

  DOI：

  10.1007/s00706-007-0656-8
• 作为产物：
  描述：

  3-乙酰基吡啶 在 氢氧化钾 、 sodium acetate 、 二乙胺 、 三乙胺 作用下， 以 乙醇 、 乙酸酐 、 溶剂黄146 为溶剂， 反应 4.0h， 生成 5-(4-methoxyphenyl)-7-(pyridin-3-yl)-5H-thiazolo[3,2-a]pyrimidin-3(2H)-one
  参考文献：
  名称：

  Synthesis, Analgesic, and Antiparkinsonian Profiles of Some Pyridine, Pyrazoline, and Thiopyrimidine Derivatives

  摘要：

  A series of substituted pyridine, pyrazoline, and thiopyrimidine derivatives were synthesized from 3-acetylpyridine, which was prepared from nicotinic acid as a naturally starting material. The pharmacological screening showed that many of these compounds have good analgesic and antiparkinsonian activities comparable to Voltarene (R) and Benzatropine (R) as reference drugs. The structure assignment of the new compounds is based on chemical and spectroscopic evidence. The detailed synthesis, spectroscopic data, and pharmacological properties for synthesized compounds are reported.

  DOI：

  10.1007/s00706-007-0656-8

文献信息

• Synthesis, Analgesic, and Antiparkinsonian Profiles of Some Pyridine, Pyrazoline, and Thiopyrimidine Derivatives
  作者：Nehad A. Abdel-Latif、Nermien M. Sabry、Ashraf M. Mohamed、Mohamed M. Abdulla

  DOI：10.1007/s00706-007-0656-8

  日期：2007.7

  A series of substituted pyridine, pyrazoline, and thiopyrimidine derivatives were synthesized from 3-acetylpyridine, which was prepared from nicotinic acid as a naturally starting material. The pharmacological screening showed that many of these compounds have good analgesic and antiparkinsonian activities comparable to Voltarene (R) and Benzatropine (R) as reference drugs. The structure assignment of the new compounds is based on chemical and spectroscopic evidence. The detailed synthesis, spectroscopic data, and pharmacological properties for synthesized compounds are reported.