| 1592771-88-4

• 分子结构分类: 有机化合物 - 有机氧化合物
• CAS: 1592771-88-4
• 化学式: C₃₉H₄₈O₅Si
• 分子量: 624.893
• InChiKey: BYWRWXQIGUHNMO-WIQNKZILSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  6.66
• 重原子数：
  45.0
• 可旋转键数：
  13.0
• 环数：
  5.0
• sp3杂化的碳原子比例：
  0.38
• 拓扑面积：
  57.15
• 氢给体数：
  1.0
• 氢受体数：
  5.0

反应信息

• 作为反应物：
  描述：

  在 四丁基氟化铵 作用下， 以 四氢呋喃 为溶剂， 反应 0.25h， 以93%的产率得到
  参考文献：
  名称：

  Stereoinversion of a Tertiary Alcohol on a THP Ring: a Recovery Route to an Intermediate for Gymnocin-A

  摘要：

  The stereoinversion of a tertiary alcohol on a tetrahydropyran ring was achieved through a five-step sequence including regioselective dehydration, diastereoselective epoxidation and reduction. This approach offers a recovery route from the diastereomer to the desired tertiary alcohol as part of the synthesis of gymnocin-A.

  DOI：

  10.3987/com-17-s(t)8
• 作为产物：
  描述：

  在 三乙基硼氢化锂 作用下， 以 四氢呋喃 为溶剂， 反应 7.0h， 以30%的产率得到
  参考文献：
  名称：

  Stereoinversion of a Tertiary Alcohol on a THP Ring: a Recovery Route to an Intermediate for Gymnocin-A

  摘要：

  The stereoinversion of a tertiary alcohol on a tetrahydropyran ring was achieved through a five-step sequence including regioselective dehydration, diastereoselective epoxidation and reduction. This approach offers a recovery route from the diastereomer to the desired tertiary alcohol as part of the synthesis of gymnocin-A.

  DOI：

  10.3987/com-17-s(t)8

文献信息

• Synthesis of the KLMN Fragment of Gymnocin-A Using Oxiranyl Anion Convergent Methodology
  作者：Takeo Sakai、Haruka Asano、Kyoko Furukawa、Rie Oshima、Yuji Mori

  DOI：10.1021/ol500788c

  日期：2014.4.18

  Synthesis of the KLMN fragment of gymnocin-A has been achieved by a [X + 2 + Y]-type convergent strategy involving the coupling of a K-ring triflate and an N-ring epoxy sulfone. Fusions of the L ring and the M ring were carried out by intramolecular S(N)2 substitution of a tertiary alcohol and reductive etherification to furnish the target molecule.