6-fluoro-8-((3S,4R)-3-fluoropiperidin-4-yloxy)-2-(7-(2-methoxyethoxy)imidazo[1,2-a]pyridin-3-yl)quinoline | 1220100-18-4

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 喹啉及其衍生物
• 英文名称: 6-fluoro-8-((3S,4R)-3-fluoropiperidin-4-yloxy)-2-(7-(2-methoxyethoxy)imidazo[1,2-a]pyridin-3-yl)quinoline
• 英文别名: 6-fluoro-8-[(3S,4R)-3-fluoropiperidin-4-yl]oxy-2-[7-(2-methoxyethoxy)imidazo[1,2-a]pyridin-3-yl]quinoline
• CAS: 1220100-18-4
• 化学式: C₂₄H₂₄F₂N₄O₃
• 分子量: 454.476
• InChiKey: XSEPWAKOMGUUGZ-GHTZIAJQSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  3.8
• 重原子数：
  33
• 可旋转键数：
  7
• 环数：
  5.0
• sp3杂化的碳原子比例：
  0.33
• 拓扑面积：
  69.9
• 氢给体数：
  1
• 氢受体数：
  8

文献信息

• IMIDAZO[1,2-A]PYRIDINE COMPOUNDS AS RECEPTOR TYROSINE KINASE INHIBITORS
  申请人：Allen Shelley

  公开号：US20100029633A1

  公开（公告）日：2010-02-04

  Compounds of Formula I: in which A, B, R 1 , R 1a , R 2 , R 3 , R 4 , R 5 R 6 , R 7 and R 8 have the meanings given in the specification, are receptor tyrosine inhibitors useful in the treatment of diseases mediated by class 3 and class 5 receptor tyrosine kinases. Particular compounds of this invention have also been found to be inhibitors of Pim- 1 .

  式I的化合物：其中A、B、R1、R1a、R2、R3、R4、R5R6、R7和R8具有规范中给出的含义，是在治疗由类3和类5受体酪氨酸激酶介导的疾病中有用的受体酪氨酸激酶抑制剂。本发明的特定化合物也被发现是Pim-1的抑制剂。
• Imidazo[1,2-a]Pyridine Compounds As Receptor Tyrosine Kinase Inhibitors
  申请人：Allen Shelley

  公开号：US20110184013A1

  公开（公告）日：2011-07-28

  Compounds of Formula I and II: I II having the chemical names cis-6-fluoro-8-(3-fluoropiperidin-4-yloxy)-2-(7-(2-methoxyethoxy)imidazo[1,2-a]pyridin-3-yl)quinoline and 6-fluoro-8-(trans-3-fluoropiperidin-4-yloxy)-2-(7-(2-methoxyethoxy)imidazo[1,2-a]pyridin-3-yl)quinoline, respectively, and enantiomers and pharmaceutically acceptable salts thereof, are receptor tyrosine inhibitors useful in the treatment of diseases mediated by class 3 and class 5 receptor tyrosine kinases. The compounds of this invention have also been found to be inhibitors of Pim-1.

  公式I和II的化合物：I II，其化学名称分别为顺式-6-氟-8-(3-氟哌啶-4-氧基)-2-(7-(2-甲氧基乙氧基)咪唑[1,2-a]吡啶-3-基)喹啉和6-氟-8-(反-3-氟哌啶-4-氧基)-2-(7-(2-甲氧基乙氧基)咪唑[1,2-a]吡啶-3-基)喹啉，其对映异构体和药学上可接受的盐，是受体酪氨酸激酶抑制剂，可用于治疗由第3类和第5类受体酪氨酸激酶介导的疾病。本发明的化合物还被发现是Pim-1的抑制剂。
• [EN] IMIDAZO [1, 2-A] PYRIDINE COMPOUNDS AS RECEPTOR TYROSINE KINASE INHIBITORS<br/>[FR] COMPOSÉS D'IMIDAZO[1,2A]PYRIDINE EN TANT QUE TYROSINE KINASE DE RÉCEPTEUR
  申请人：ARRAY BIOPHARMA INC

  公开号：WO2010039825A3

  公开（公告）日：2010-10-07
• US8138181B2
  申请人：——

  公开号：US8138181B2

  公开（公告）日：2012-03-20
• [EN] IMIDAZO[1,2-a]PYRIDINE COMPOUNDS AS RECEPTOR TYROSINE KINASE INHIBITORS<br/>[FR] COMPOSÉS D'IMIDAZO[1,2A]PYRIDINE EN TANT QUE TYROSINE KINASE DE RÉCEPTEUR
  申请人：ARRAY BIOPHARMA INC

  公开号：WO2010039825A2

  公开（公告）日：2010-04-08

  Compounds of Formula I and II: I II having the chemical names cis-6-fluoro-8-(3-fluoropiperidin-4-yloxy)-2-(7-(2-methoxyethoxy)imidazo[1,2-a]pyridin-3-yl)quinoline and 6-fluoro-8-(trans-3-fluoropiperidin-4-yloxy)-2-(7-(2-methoxyethoxy)imidazo[1,2-a]pyridin-3-yl)quinoline, respectively, and enantiomers and pharmaceutically acceptable salts thereof, are receptor tyrosine inhibitors useful in the treatment of diseases mediated by class 3 and class 5 receptor tyrosine kinases. The compounds of this invention have also been found to be inhibitors of Pim-1.