7-(4-methoxyphenyl)-3-methyl-4-[2-(methyl{2-[2-(2-oxo(6-hydroquinolyloxy))acetylamino]ethyl}amino)ethyl]-5-oxo-2-phenyl-6H,7H-1,4-thiazepin-6-yl acetate | 1044659-86-0

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 喹啉及其衍生物
• 英文名称: 7-(4-methoxyphenyl)-3-methyl-4-[2-(methyl{2-[2-(2-oxo(6-hydroquinolyloxy))acetylamino]ethyl}amino)ethyl]-5-oxo-2-phenyl-6H,7H-1,4-thiazepin-6-yl acetate
• 英文别名: [7-(4-methoxyphenyl)-3-methyl-4-[2-[methyl-[2-[[2-[(2-oxo-1H-quinolin-6-yl)oxy]acetyl]amino]ethyl]amino]ethyl]-5-oxo-2-phenyl-6,7-dihydro-1,4-thiazepin-6-yl] acetate
• CAS: 1044659-86-0
• 化学式: C₃₇H₄₀N₄O₇S
• 分子量: 684.813
• InChiKey: ABBNGSZNQYABOZ-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  4.1
• 重原子数：
  49
• 可旋转键数：
  14
• 环数：
  5.0
• sp3杂化的碳原子比例：
  0.3
• 拓扑面积：
  152
• 氢给体数：
  2
• 氢受体数：
  9

文献信息

• [EN] COMPOUNDS WITH PHOSPHODIESTERASE INHIBITING AND CALCIUM CHANNEL BLOCKING ACTIVITIES<br/>[FR] COMPOSES EXERÇANT UNE ACTIVITE INHIBITRICE DE LA PHOSPHODIESTERASE ET UNE ACTIVITE DE BLOCAGE DE LA VOIE CALCIUM
  申请人：ARTESIAN THERAPEUTICS INC

  公开号：WO2005035505A2

  公开（公告）日：2005-04-21

  The present invention provides compounds that possess inhibitory activity against PDE-3 and L-type calcium channels. The present invention further provides pharmaceutical compositions comprising such compounds and methods of using such compounds for treating cardiovascular disease, stroke, epilepsy, ophthalmic disorder or migraine.