1-(2-hydroxyphenyl)-2-(3-nitropyridin-4-yl)ethanone | 1417637-32-1

• 分子结构分类: 有机化合物 - 有机氧化合物
• 英文名称: 1-(2-hydroxyphenyl)-2-(3-nitropyridin-4-yl)ethanone
• 英文别名: 1-(2-Hydroxyphenyl)-2-(3-nitropyridin-4-yl)ethanone
• CAS: 1417637-32-1
• 化学式: C₁₃H₁₀N₂O₄
• 分子量: 258.233
• InChiKey: YLGQZANNRBOZAQ-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  2.2
• 重原子数：
  19
• 可旋转键数：
  3
• 环数：
  2.0
• sp3杂化的碳原子比例：
  0.08
• 拓扑面积：
  96
• 氢给体数：
  1
• 氢受体数：
  5

反应信息

• 作为产物：
  描述：

  4-氯-3-硝基吡啶 、 2'-羟基苯乙酮 在 caesium carbonate 作用下， 以 乙腈 为溶剂， 反应 1.0h， 以91%的产率得到1-(2-hydroxyphenyl)-2-(3-nitropyridin-4-yl)ethanone
  参考文献：
  名称：

  An efficient C–C bond formation reaction for the synthesis of α-arylated ketones under mild conditions

  摘要：

  A wide range of substituted alpha-arylated ketones were synthesized in moderate to excellent yields via a Truce Smiles rearrangement. The main scaffold has various applications in medical and biochemical fields. This process also provides a facile and direct method for the C-C bond formation. (C) 2012 Elsevier Ltd. All rights reserved.

  DOI：

  10.1016/j.tetlet.2012.11.024

文献信息

• An efficient C–C bond formation reaction for the synthesis of α-arylated ketones under mild conditions
  作者：Yanli Liu、Xinhai Zhang、Ying Ma、Chen Ma

  DOI：10.1016/j.tetlet.2012.11.024

  日期：2013.1

  A wide range of substituted alpha-arylated ketones were synthesized in moderate to excellent yields via a Truce Smiles rearrangement. The main scaffold has various applications in medical and biochemical fields. This process also provides a facile and direct method for the C-C bond formation. (C) 2012 Elsevier Ltd. All rights reserved.