(E)-Labd-13-en-8α-ol | 10267-35-3

• 分子结构分类: 有机化合物 - 有机氧化合物
• 英文名称: (E)-Labd-13-en-8α-ol
• 英文别名: Labd-13-en-8α-ol；Labd-13E-en-8-ol；8α-Hydroxy...-(E)-13(14)en；(1R,2R,4aS,8aS)-2,5,5,8a-tetramethyl-1-[(E)-3-methylpent-3-enyl]-3,4,4a,6,7,8-hexahydro-1H-naphthalen-2-ol
• CAS: 10267-35-3
• 化学式: C₂₀H₃₆O
• 分子量: 292.505
• InChiKey: SBAKCUQZQGDQSU-RSDFSZQVSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  6.4
• 重原子数：
  21
• 可旋转键数：
  3
• 环数：
  2.0
• sp3杂化的碳原子比例：
  0.9
• 拓扑面积：
  20.2
• 氢给体数：
  1
• 氢受体数：
  1

反应信息

• 作为产物：
  描述：

  manoyl oxide 在 lithium 、 乙胺 作用下， 以 四氢呋喃 为溶剂， 反应 4.0h， 生成 (E)-Labd-13-en-8α-ol 、 (Z)-Labd-13-en-8α-ol
  参考文献：
  名称：

  Synthesis of a Novel Diterpenoid Rearrangement Product

  摘要：

  我们合成并耦合了唇形二萜八氢-二萘并吡喃酮（2）重排为八氢萘并呋喃酮（4）过程中的两个中间产物，从而为之前提出的重排机制提供了支持。

  DOI：

  10.1071/ch9951747

文献信息

• Polypeptides with diterpene synthase activity
  申请人：Technical University of Denmark

  公开号：EP2886647A1

  公开（公告）日：2015-06-24

  The present invention relates to polypeptides with diterpene synthase activity. The invention further relates to polynucleotides encoding such polypeptides. Also provided are vectors for expression of the polypeptides and host cells expressing the polypeptides.

  本发明涉及具有二萜合成酶活性的多肽。本发明还涉及编码这种多肽的多核苷酸。还提供了表达多肽的载体和表达多肽的宿主细胞。
• STEREO-SPECIFIC SYNTHESIS OF (13R)-MANOYL OXIDE
  申请人：Technical University of Denmark

  公开号：EP3083975A1

  公开（公告）日：2016-10-26
• METHODS FOR PRODUCING DITERPENES
  申请人：University of Copenhagen

  公开号：EP3099803A1

  公开（公告）日：2016-12-07
• Methods for Producing Diterpenes
  申请人：University of Copenhagen

  公开号：US20180037912A1

  公开（公告）日：2018-02-08

  The present invention discloses that by combining different di TPS enzymes of class I and class II different diterpenes may be produced including diterpenes not identified in nature. Surprisingly it is revealed that a di TPS enzyme of class I of one species may be combined with a di TPS enzyme of class II from a different species, resulting in a high diversity of diterpenes, which can be produced.
• [EN] METHODS FOR PRODUCING DITERPENES<br/>[FR] PROCÉDÉS DE PRODUCTION DE DITERPÈNES
  申请人：UNIV COPENHAGEN

  公开号：WO2015113570A1

  公开（公告）日：2015-08-06

  The present invention discloses that by combining different di TPS enzymes of class I and class II different diterpenes may be produced including diterpenes not identified in nature. Surprisingly it is revealed that a di TPS enzyme of class I of one species may be combined with a di TPS enzyme of class II from a different species, resulting in a high diversity of diterpenes, which can be produced.