8-methyl-quinoline-3-carboxamide | 71083-36-8

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 喹啉及其衍生物
• 英文名称: 8-methyl-quinoline-3-carboxamide
• 英文别名: 8-methyl-3-quinolinecarboxamide；8-Methylquinoline-3-carboxamide
• CAS: 71083-36-8
• 化学式: C₁₁H₁₀N₂O
• 分子量: 186.213
• InChiKey: BRRAAVRHYYQTFP-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  1.4
• 重原子数：
  14
• 可旋转键数：
  1
• 环数：
  2.0
• sp3杂化的碳原子比例：
  0.09
• 拓扑面积：
  56
• 氢给体数：
  1
• 氢受体数：
  2

文献信息

• [EN] INHIBITORS OF HIF PROLYL HYDROXYLASE<br/>[FR] INHIBITEURS DE LA PROLYL HYDROXYLASE DU HIF
  申请人：MERCK SHARP & DOHME

  公开号：WO2016045125A1

  公开（公告）日：2016-03-31

  Disclosed are a compound of formula I or a pharmaceutically acceptable salt thereof, which inhibit HIF prolyl hydroxylase, their use for enhancing endogenous production of erythropoietin, and for treating conditions associated with reduced endogenous production of erythropoietin such as anemia and like conditions, as well as pharmaceutical compositions comprising such a compound and a pharmaceutical carrier.