4-丙酮基-5-甲基-2-苯基-1,2,3-三唑 | 87613-37-4

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 唑类
• 中文名称: 4-丙酮基-5-甲基-2-苯基-1,2,3-三唑
• 英文名称: 4-acetonyl-5-methyl-2-phenyl-1,2,3-triazole
• 英文别名: (5-methyl-2-phenyl-2H-[1,2,3]triazol-4-yl)-acetone；(5-Methyl-2-phenyl-2H-[1,2,3]triazol-4-yl)-aceton；1-(5-Methyl-2-phenyltriazol-4-yl)propan-2-one
• CAS: 87613-37-4
• 化学式: C₁₂H₁₃N₃O
• 分子量: 215.255
• InChiKey: ZDDFCPBGMARLFM-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  2
• 重原子数：
  16
• 可旋转键数：
  3
• 环数：
  2.0
• sp3杂化的碳原子比例：
  0.25
• 拓扑面积：
  47.8
• 氢给体数：
  0
• 氢受体数：
  3

反应信息

• 作为反应物：
  描述：

  4-丙酮基-5-甲基-2-苯基-1,2,3-三唑 在 sodium 、 亚硝酸异戊酯 作用下， 以 乙醇 为溶剂， 反应 6.0h， 以65%的产率得到1-hydroxyimino-1-(2-phenyl-5-methyl-2H-1,2,3-triazol-4-yl)-2-propanone
  参考文献：
  名称：

  合成新的2,2'-二取代的5,5'-二甲基-4,4'-三唑和2-（4-三唑基）喹喔啉

  摘要：

  3-酰基异恶唑芳基的热重排使得可以容易地制备2 H -1,2,3-三唑，其首先与亚硝酸异戊酯反应，然后与适当的芳基react反应生成相应的α-羟基亚氨基hydr 8a-h。化合物8a-h与五氯化磷反应，得到所需的4,4'-双三唑1a-h。α-羟基亚氨基酮衍生物7或α-二酮14易于与1,2-苯二胺反应，得到在位置4带有喹喔啉部分的1,2,3-三唑2a-c。提高了喹喔啉2a-c的产率当1,2-苯二胺与二肟15反应时获得

  DOI：

  10.1002/jhet.5570370221
• 作为产物：
  描述：

  N-[(Z)-1-(5-methyl-1,2-oxazol-3-yl)ethylideneamino]aniline 反应 3.0h， 以60%的产率得到4-丙酮基-5-甲基-2-苯基-1,2,3-三唑
  参考文献：
  名称：

  Vivona, Nicolo; Macaluso, Gabriella; Frenna, Vincenzo, Journal of Heterocyclic Chemistry, 1983, vol. 20, p. 931 - 934

  摘要：

  DOI：

文献信息

• Increased hsp22 RNA Levels in Drosophila Lines Genetically Selected for Increased Longevity
  作者：R. Kurapati、H. B. Passananti、M. R. Rose、J. Tower

  DOI：10.1093/gerona/55.11.b552

  日期：2000.11.1

  RNAs for the small heat shock protein (hsp) genes hsp22 and hsp23 are induced during Drosophila aging, suggesting that these genes might have specific functions at late ages. To determine if hsp22 and hsp23 gene expression might correlate with life span, RNA levels for these and additional genes were analyzed throughout the adult life span in a set of five outbred "O" lines, which have been genetically selected for increased longevity, and in five matched control "B" lines. Control ribosomal protein genes rp49 and AP3/RpPO RNA levels were similar in O and B lines. In contrast, hsp22 RNA levels were twofold-tenfold higher in all five O lines relative to all five B lines, while hsp23 exhibited a smaller but significant increase. Thus increased hsp22 and hsp23 RNA levels correlate with the increased life span and increased stress resistance of the genetically selected O lines.
• VIVONA, N.;MACALUSO, G.;FRENNA, V.;RUCCIA, M., J. HETEROCYCL. CHEM., 1983, 20, N 4, 931-934
  作者：VIVONA, N.、MACALUSO, G.、FRENNA, V.、RUCCIA, M.

  DOI：——

  日期：——
• Vivona, Nicolo; Macaluso, Gabriella; Frenna, Vincenzo, Journal of Heterocyclic Chemistry, 1983, vol. 20, p. 931 - 934
  作者：Vivona, Nicolo、Macaluso, Gabriella、Frenna, Vincenzo、Ruccia, Michele

  DOI：——

  日期：——
• Synthesis of new 2,2′-disubstituted 5,5′-dimethyl-4,4′-bitriazoles and 2-(4-Triazolyl)quinoxalines
  作者：Francesco Paolo Invidiata、Stefania Aiello、Giancarlo Furno'、Enrico Aiello、Daniele Simoni、Riccardo Rondanin

  DOI：10.1002/jhet.5570370221

  日期：2000.3

  Thermal rearrangement of 3-acylisoxazole arylhydrazones allowed facile preparation of 2H-1,2,3-triazoles which were firstly reacted with isoamyl nitrite and then with an opportune arylhydrazine to produce the corresponding α-hydroxyiminohydrazones 8a-h. The reaction of compounds 8a-h with phosphorus pentachloride afforded the desired 4,4′-bitriazoles 1a-h. The α-hydroxyiminoketone derivative 7 or the

  3-酰基异恶唑芳基的热重排使得可以容易地制备2 H -1,2,3-三唑，其首先与亚硝酸异戊酯反应，然后与适当的芳基react反应生成相应的α-羟基亚氨基hydr 8a-h。化合物8a-h与五氯化磷反应，得到所需的4,4'-双三唑1a-h。α-羟基亚氨基酮衍生物7或α-二酮14易于与1,2-苯二胺反应，得到在位置4带有喹喔啉部分的1,2,3-三唑2a-c。提高了喹喔啉2a-c的产率当1,2-苯二胺与二肟15反应时获得