1-benzyl-3-(4-benzyloxyphenyl)-1H,7H-pyrrolo[3,2-f]indole-4,8-dione | 1430737-09-9

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 吲哚及其衍生物
• 英文名称: 1-benzyl-3-(4-benzyloxyphenyl)-1H,7H-pyrrolo[3,2-f]indole-4,8-dione
• 英文别名: 1-benzyl-3-(4-phenylmethoxyphenyl)-7H-pyrrolo[3,2-f]indole-4,8-dione
• CAS: 1430737-09-9
• 化学式: C₃₀H₂₂N₂O₃
• 分子量: 458.516
• InChiKey: VWYIEAXKSLERNY-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  5.8
• 重原子数：
  35
• 可旋转键数：
  6
• 环数：
  6.0
• sp3杂化的碳原子比例：
  0.07
• 拓扑面积：
  64.1
• 氢给体数：
  1
• 氢受体数：
  3

反应信息

• 作为反应物：
  描述：

  1-benzyl-3-(4-benzyloxyphenyl)-1H,7H-pyrrolo[3,2-f]indole-4,8-dione 在 甲酸铵 、 钯 作用下， 以 乙醇 为溶剂， 反应 15.0h， 以50%的产率得到3-(4-hydroxyphenyl)-1H,7H-pyrrolo[3,2-f]indole-4,8-dione
  参考文献：
  名称：

  Total synthesis of zyzzyanones A–D

  摘要：

  Zyzzyanones A-D is a group of biologically active marine alkaloids isolated from Australian marine sponge Zyzzya fuliginosa. They contain a unique bispyrroloquinone ring system as the core structure. The first total synthesis of all four zyzzyanones is described here. The synthesis of these alkaloids started from a previously known 6-benzylamino indole-4,7-quinone derivative and involves 6-7 steps. The key step in the synthesis involves the construction of a pyrrole ring in one step using a Mn(OAc)(3) mediated oxidative free radical cyclization reaction of a 6-benzylamino indole-4,7-quinone derivative with 4-benzyloxyphenyl acetaldehyde diethyl acetal in CH3CN. (C) 2013 Elsevier Ltd. All rights reserved.

  DOI：

  10.1016/j.tet.2013.03.052
• 作为产物：
  描述：

  2-(4-苯甲氧基苯基)乙醇 在 硫酸 、 2-iodoxybenzoic acid 、 sodium methylate 、 manganese triacetate 作用下， 以 甲醇 、 二甲基亚砜 、 乙腈 为溶剂， 反应 46.75h， 生成 1-benzyl-3-(4-benzyloxyphenyl)-1H,7H-pyrrolo[3,2-f]indole-4,8-dione
  参考文献：
  名称：

  Total synthesis of zyzzyanones A–D

  摘要：

  Zyzzyanones A-D is a group of biologically active marine alkaloids isolated from Australian marine sponge Zyzzya fuliginosa. They contain a unique bispyrroloquinone ring system as the core structure. The first total synthesis of all four zyzzyanones is described here. The synthesis of these alkaloids started from a previously known 6-benzylamino indole-4,7-quinone derivative and involves 6-7 steps. The key step in the synthesis involves the construction of a pyrrole ring in one step using a Mn(OAc)(3) mediated oxidative free radical cyclization reaction of a 6-benzylamino indole-4,7-quinone derivative with 4-benzyloxyphenyl acetaldehyde diethyl acetal in CH3CN. (C) 2013 Elsevier Ltd. All rights reserved.

  DOI：

  10.1016/j.tet.2013.03.052

文献信息

• Total synthesis of zyzzyanones A–D
  作者：Dwayaja H. Nadkarni、Srinivasan Murugesan、Sadanandan E. Velu

  DOI：10.1016/j.tet.2013.03.052

  日期：2013.5

  Zyzzyanones A-D is a group of biologically active marine alkaloids isolated from Australian marine sponge Zyzzya fuliginosa. They contain a unique bispyrroloquinone ring system as the core structure. The first total synthesis of all four zyzzyanones is described here. The synthesis of these alkaloids started from a previously known 6-benzylamino indole-4,7-quinone derivative and involves 6-7 steps. The key step in the synthesis involves the construction of a pyrrole ring in one step using a Mn(OAc)(3) mediated oxidative free radical cyclization reaction of a 6-benzylamino indole-4,7-quinone derivative with 4-benzyloxyphenyl acetaldehyde diethyl acetal in CH3CN. (C) 2013 Elsevier Ltd. All rights reserved.