4-Methyl-N-((R)-1-methyl-dec-9-enyl)-benzenesulfonamide | 214190-58-6

• 分子结构分类: 有机化合物 - 苯类化合物 - 苯和取代衍生物
• 英文名称: 4-Methyl-N-((R)-1-methyl-dec-9-enyl)-benzenesulfonamide
• CAS: 214190-58-6
• 化学式: C₁₈H₂₉NO₂S
• 分子量: 323.5
• InChiKey: XCOXMCSSOOLHGV-QGZVFWFLSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  4.58
• 重原子数：
  22.0
• 可旋转键数：
  11.0
• 环数：
  1.0
• sp3杂化的碳原子比例：
  0.56
• 拓扑面积：
  46.17
• 氢给体数：
  1.0
• 氢受体数：
  2.0

反应信息

• 作为反应物：
  描述：

  4-Methyl-N-((R)-1-methyl-dec-9-enyl)-benzenesulfonamide 在 硼烷四氢呋喃络合物 、 乙酸酐 、 sodium naphthalenide 、 sodium hydride 、 pyridinium chlorochromate 作用下， 以 四氢呋喃 、 乙二醇二甲醚 、 乙酸乙酯 为溶剂， 生成 (R)-8-{tert-Butoxycarbonyl-[2-(tert-butyl-dimethyl-silanyloxy)-ethyl]-amino}-nonanoic acid
  参考文献：
  名称：

  Absolute configuration of the polyazamacrolides, macrocyclic polyamines produced by a ladybird beetle

  摘要：

  The absolute configuration of the polyazamacrolides, oligomeric macrocycles from the pupal defensive secretion of Epilachna borealis, was determined by comparison of derivatives of the natural material with enantiomerically pure synthetic samples. Samples of a mixture of three (omega-l)-(2-hydroxyethylamino)alkanoic acids and of the corresponding aza-lactones were synthesized from (R)-alaninol. Gas chromatographic comparison of MTPA-amides of the synthetic aza-lactones with the MTPA-amides of aza-lactones prepared from the natural material established that the polyazamacrolides have the (R)-configuration at all stereogenic centers. (C) 1998 Elsevier Science Ltd. All rights reserved.

  DOI：

  10.1016/s0040-4039(98)01404-x
• 作为产物：
  描述：

  N-[(2R)-1-羟基-2-丙基]-4-甲基苯磺酰胺 在 copper(l) iodide 、 potassium carbonate 作用下， 以 乙醚 、 丙酮 为溶剂， 生成 4-Methyl-N-((R)-1-methyl-dec-9-enyl)-benzenesulfonamide
  参考文献：
  名称：

  Absolute configuration of the polyazamacrolides, macrocyclic polyamines produced by a ladybird beetle

  摘要：

  The absolute configuration of the polyazamacrolides, oligomeric macrocycles from the pupal defensive secretion of Epilachna borealis, was determined by comparison of derivatives of the natural material with enantiomerically pure synthetic samples. Samples of a mixture of three (omega-l)-(2-hydroxyethylamino)alkanoic acids and of the corresponding aza-lactones were synthesized from (R)-alaninol. Gas chromatographic comparison of MTPA-amides of the synthetic aza-lactones with the MTPA-amides of aza-lactones prepared from the natural material established that the polyazamacrolides have the (R)-configuration at all stereogenic centers. (C) 1998 Elsevier Science Ltd. All rights reserved.

  DOI：

  10.1016/s0040-4039(98)01404-x