6-iodo-8,4-dimethylquinoline | 261636-07-1

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 喹啉及其衍生物
• 英文名称: 6-iodo-8,4-dimethylquinoline
• 英文别名: 6-Iodo-4,8-dimethylquinoline
• CAS: 261636-07-1
• 化学式: C₁₁H₁₀IN
• 分子量: 283.112
• InChiKey: UACXZBJPKKZNJC-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  3.6
• 重原子数：
  13
• 可旋转键数：
  0
• 环数：
  2.0
• sp3杂化的碳原子比例：
  0.18
• 拓扑面积：
  12.9
• 氢给体数：
  0
• 氢受体数：
  1

反应信息

• 作为产物：
  描述：

  4-碘-2-甲基苯胺 、 丁烯酮 在 indium(III) chloride 、 silica gel 作用下， 反应 0.17h， 以83%的产率得到6-iodo-8,4-dimethylquinoline
  参考文献：
  名称：

  Microwave-assisted simple synthesis of quinolines from anilines and alkyl vinyl ketones on the surface of silica gel in the presence of indium(III) chloride

  摘要：

  A simple and efficient procedure has been developed for the synthesis of 4-alkylquinolines by a one-pot reaction of anilines with alkyl vinyl ketones on the surface of silica gel impregnated with indium(III) chloride under microwave irradiation without any solvent. (C) 2000 Elsevier Science Ltd. All rights reserved.

  DOI：

  10.1016/s0040-4039(99)02111-5

文献信息

• Efficient microwave-assisted synthesis of quinolines and dihydroquinolines under solvent-free conditions
  作者：Brindaban C Ranu、Alakananda Hajra、Suvendu S Dey、Umasish Jana

  DOI：10.1016/s0040-4020(02)01587-9

  日期：2003.2

  A convenient and efficient procedure for the synthesis of quinolines and dihydroquinolines has been developed by a simple one-pot reaction of anilines with alkyl vinyl ketones on the surface of silica gel impregnated with indium(III) chloride under microwave irradiation without any solvent. (C) 2003 Elsevier Science Ltd. All tights reserved.