3'-(trifluoromethyl)-1',4',6',7'-tetrahydrospiro[1,3-dioxolane-2,5'-indazole] | 1092459-45-4

• 分子结构分类: 有机化合物 - 有机氧化合物
• 英文名称: 3'-(trifluoromethyl)-1',4',6',7'-tetrahydrospiro[1,3-dioxolane-2,5'-indazole]
• 英文别名: 3'-(Trifluoromethyl)-1',4',6',7'-tetrahydrospiro[[1,3]dioxolane-2,5'-indazole]；3'-(trifluoromethyl)spiro[1,3-dioxolane-2,5'-1,4,6,7-tetrahydroindazole]
• CAS: 1092459-45-4
• 化学式: C₁₀H₁₁F₃N₂O₂
• 分子量: 248.205
• InChiKey: FVZMHORKMDVJBU-UHFFFAOYSA-N

物化性质

• 沸点：
  352.3±37.0 °C(Predicted)
• 密度：
  1.47±0.1 g/cm3(Predicted)

计算性质

• 辛醇/水分配系数(LogP)：
  1.3
• 重原子数：
  17
• 可旋转键数：
  0
• 环数：
  3.0
• sp3杂化的碳原子比例：
  0.7
• 拓扑面积：
  47.1
• 氢给体数：
  1
• 氢受体数：
  6

反应信息

• 作为反应物：
  描述：

  (4-iodophenyl)(pyrrolidin-1-yl)methanone 、 3'-(trifluoromethyl)-1',4',6',7'-tetrahydrospiro[1,3-dioxolane-2,5'-indazole] 在 copper(l) iodide 、 N,N-二甲基甘氨酸 potassium carbonate 作用下， 以 二甲基亚砜 为溶剂， 反应 6.0h， 以35%的产率得到1'-[4-(1-pyrrolidinylcarbonyl)phenyl]-3'-(trifluoromethyl)-1',4',6',7'-tetrahydrospiro[1,3-dioxolane-2,5'-indazole]
  参考文献：
  名称：

  WO2008/148832

  摘要：

  公开号：
• 作为产物：
  描述：

  7-(trifluoroacetyl)-1,4-dioxaspiro[4.5]decan-8-one 在 肼 作用下， 以 乙醇 为溶剂， 反应 1.0h， 以92%的产率得到3'-(trifluoromethyl)-1',4',6',7'-tetrahydrospiro[1,3-dioxolane-2,5'-indazole]
  参考文献：
  名称：

  WO2008/148832

  摘要：

  公开号：

文献信息

• COMPOUNDS FOR THE TREATMENT OF HIV
  申请人：Bondy Steven S.

  公开号：US20140142085A1

  公开（公告）日：2014-05-22

  The invention provides compounds of formula (I): or a salt thereof as described herein. The invention also provides pharmaceutical compositions comprising a compound of formula (I), processes for preparing compounds of formula (I), intermediates useful for preparing compounds of formula I and therapeutic methods for treating a Retroviridae viral infection including an infection caused by the HIV virus.

  本发明提供了以下式子（I）的化合物或其盐，如本文所述。本发明还提供了包括式子（I）化合物的制药组合物，制备式子（I）化合物的方法，用于制备式子I化合物的中间体以及治疗逆转录病毒感染的治疗方法，包括由HIV病毒引起的感染。
• Therapeutic compounds
  申请人：Gilead Sciences, Inc.

  公开号：US10202353B2

  公开（公告）日：2019-02-12

  Compounds of Formula I, or salts thereof, are disclosed. Also disclosed are pharmaceutical compositions comprising a compound of Formula I, processes for preparing compounds of Formula I, intermediates useful for preparing compounds of Formula I and therapeutic, methods for treating a Retroviridae viral infection, in particular infection caused by the HIV virus.

  公开了式 I 化合物或其盐类。还公开了包含式 I 化合物的药物组合物、制备式 I 化合物的工艺、用于制备式 I 化合物的中间体以及治疗逆转录病毒科病毒感染（尤其是由 HIV 病毒引起的感染）的方法。
• Compounds for the treatment of HIV
  申请人：Gilead Sciences, Inc.

  公开号：US10370358B2

  公开（公告）日：2019-08-06

  The invention provides compounds of formula (I): or a salt thereof as described herein. The invention also provides pharmaceutical compositions comprising a compound of formula (I), processes for preparing compounds of formula (I), intermediates useful for preparing compounds of formula I and therapeutic methods for treating a Retroviridae viral infection including an infection caused by the HIV virus.

  本发明提供如本文所述的式(I)化合物或其盐。本发明还提供了包含式（I）化合物的药物组合物、制备式（I）化合物的工艺、用于制备式（I）化合物的中间体以及治疗逆转录病毒科病毒感染（包括由 HIV 病毒引起的感染）的治疗方法。
• THERAPEUTIC COMPOUNDS
  申请人：Gilead Sciences, Inc..

  公开号：US20160368881A1

  公开（公告）日：2016-12-22

  Compounds of Formula I: or salts thereof are disclosed. Also disclosed are pharmaceutical compositions comprising a compound of Formula I, processes for preparing compounds of Formula I, intermediates useful for preparing compounds of Formula I and therapeutic, methods for treating a Retroviridae viral infection, in particular infection caused by the HIV virus.
• Compounds For the Treatment of HIV
  申请人：Gilead Sciences, Inc.

  公开号：US20180194746A1

  公开（公告）日：2018-07-12

  The invention provides compounds of formula (I): or a salt thereof as described herein. The invention also provides pharmaceutical compositions comprising a compound of formula (I), processes for preparing compounds of formula (I), intermediates useful for preparing compounds of formula I and therapeutic methods for treating a Retroviridae viral infection including an infection caused by the HIV virus.