2-[[7-(Cyclohexylamino)-6-fluoro-4-oxo-1-pentan-3-ylquinolin-3-yl]amino]acetic acid | 950495-37-1

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 喹啉及其衍生物
• 英文名称: 2-[[7-(Cyclohexylamino)-6-fluoro-4-oxo-1-pentan-3-ylquinolin-3-yl]amino]acetic acid
• CAS: 950495-37-1
• 化学式: C₂₂H₃₀FN₃O₃
• 分子量: 403.497
• InChiKey: LCHUDGFBYYNUAL-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  5.2
• 重原子数：
  29
• 可旋转键数：
  8
• 环数：
  3.0
• sp3杂化的碳原子比例：
  0.55
• 拓扑面积：
  81.7
• 氢给体数：
  3
• 氢受体数：
  7

文献信息

• QUINOLONE DERIVATIVE OR PHARMACEUTICALLY ACCEPTABLE SALT THEREOF
  申请人：Koga Yuji

  公开号：US20090197834A1

  公开（公告）日：2009-08-06

  [Problem] To provide a compound having excellent platelet aggregation inhibitory activity. [Means for Resolution] It was found that quinolone derivatives characterized in that these have lower alkyl, cycloalkyl or the like at the 1-position; —N(R 0 )C(O)-lower alkylene-CO 2 R 0 , lower alkylene-CO 2 R 0 , lower alkenylene-CO 2 R 0 , —O-lower alkylene-CO 2 R 0 , —O-(lower alkylene which may be substituted with —CO 2 R 0 )-aryl or —O-lower alkenylene-CO 2 R 0 (wherein R 0 is H or lower alkyl) at the 3-position; halogen at the 6-position; and amino group substituted with a substituent group having a ring structure at the 7-position, respectively, or pharmaceutically acceptable salts thereof, has excellent P2Y12 inhibitory activity. In addition, it was confirmed that these quinolone derivatives also have excellent platelet aggregation inhibitory activity. Based on the above, these quinolone derivatives or pharmaceutically acceptable salts thereof are useful as platelet aggregation inhibitors.

  [问题] 提供一种具有出色的血小板聚集抑制活性的化合物。[解决方法] 发现在喹诺酮衍生物中，其在1-位置具有较低烷基，环烷基或类似物；在3-位置具有—N（R0）C（O）-较低烷基-CO2R0，较低烷基-CO2R0，较低烯基-CO2R0，—O-较低烷基-CO2R0，—O-（可能被取代为—CO2R0）-芳基或—O-较低烯基-CO2R0（其中R0为H或较低烷基）的特征喹诺酮衍生物；在6-位置具有卤素；在7-位置具有被含有环结构的取代基取代的氨基基团，或其药学上可接受的盐，具有出色的P2Y12抑制活性。此外，确认这些喹诺酮衍生物也具有出色的血小板聚集抑制活性。基于上述，这些喹诺酮衍生物或其药学上可接受的盐可用作血小板聚集抑制剂。
• EP1995240A1
  申请人：——

  公开号：EP1995240A1

  公开（公告）日：2008-11-26
• US8629126B2
  申请人：——

  公开号：US8629126B2

  公开（公告）日：2014-01-14