diethyl 3-(phenylcarbamoyl)-2-(ethylthio)-6-(4-methoxyphenyl)-4-oxocyclohex-2-ene-1,1-dicarboxylate | 1262340-28-2

• 分子结构分类: 有机化合物 - 苯类化合物 - 苯酚醚
• 英文名称: diethyl 3-(phenylcarbamoyl)-2-(ethylthio)-6-(4-methoxyphenyl)-4-oxocyclohex-2-ene-1,1-dicarboxylate
• CAS: 1262340-28-2
• 化学式: C₂₈H₃₁NO₇S
• 分子量: 525.623
• InChiKey: AANSALJJASEQQR-UHFFFAOYSA-N

反应信息

• 作为反应物：
  描述：

  diethyl 3-(phenylcarbamoyl)-2-(ethylthio)-6-(4-methoxyphenyl)-4-oxocyclohex-2-ene-1,1-dicarboxylate 在 potassium carbonate 作用下， 以 N,N-二甲基甲酰胺 为溶剂， 反应 1.0h， 生成 diethyl 2-((2E,4E)-2-(phenylcarbamoyl)-1-(ethylthio)-3-hydroxy-5-(4-methoxyphenyl)penta-2,4-dienylidene)malonate
  参考文献：
  名称：

  Efficient synthesis of highly functionalized vinylogous thiol esters

  摘要：

  A series of vinylogous thiol esters 2,3 and 2,6-dioxo-1,2,5,6-tetrahydropyridines (cyclic vinylogous thiol esters) 4 were prepared in high to excellent yields from the tandem reaction of readily available alpha-alkenoylketene diethylthioacetals 1 and diethyl malonate. A plausible mechanism, which involves a base catalyzed retro-Michael ring opening of cyclohexanenes 2 to give vinylogous thiol ester 3, is disclosed. Crown Copyright (C) 2010 Published by Elsevier Ltd. All rights reserved.

  DOI：

  10.1016/j.tetlet.2010.10.129
• 作为产物：
  描述：

  (E)-2-(bis(ethylthio)methylene)-5-(4-methoxyphenyl)-3-oxo-N-phenylpent-4-enamide 、 丙二酸二乙酯 在 potassium carbonate 作用下， 以 N,N-二甲基甲酰胺 为溶剂， 反应 4.0h， 以85%的产率得到diethyl 3-(phenylcarbamoyl)-2-(ethylthio)-6-(4-methoxyphenyl)-4-oxocyclohex-2-ene-1,1-dicarboxylate
  参考文献：
  名称：

  Efficient synthesis of highly functionalized vinylogous thiol esters

  摘要：

  A series of vinylogous thiol esters 2,3 and 2,6-dioxo-1,2,5,6-tetrahydropyridines (cyclic vinylogous thiol esters) 4 were prepared in high to excellent yields from the tandem reaction of readily available alpha-alkenoylketene diethylthioacetals 1 and diethyl malonate. A plausible mechanism, which involves a base catalyzed retro-Michael ring opening of cyclohexanenes 2 to give vinylogous thiol ester 3, is disclosed. Crown Copyright (C) 2010 Published by Elsevier Ltd. All rights reserved.

  DOI：

  10.1016/j.tetlet.2010.10.129