2,8-dimethoxy-10-(4-methylpiperazin-1-ylmethyl)-5-thia-4b-aza-indeno[2,1-a]indene-5,5-dioxide | 713124-09-5

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 吲哚及其衍生物
• 英文名称: 2,8-dimethoxy-10-(4-methylpiperazin-1-ylmethyl)-5-thia-4b-aza-indeno[2,1-a]indene-5,5-dioxide
• 英文别名: 2,9-Dimethoxy-11-[(4-methylpiperazin-1-yl)methyl]indolo[1,2-b][1,2]benzothiazole 5,5-dioxide
• CAS: 713124-09-5
• 化学式: C₂₂H₂₅N₃O₄S
• 分子量: 427.524
• InChiKey: IMMAHQDCGDNBIV-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  2.6
• 重原子数：
  30
• 可旋转键数：
  4
• 环数：
  5.0
• sp3杂化的碳原子比例：
  0.36
• 拓扑面积：
  72.4
• 氢给体数：
  0
• 氢受体数：
  6

文献信息

• [EN] TETRACYCLIC 3-SUBSTITUTED INDOLES HAVING SEROTONIN RECEPTOR AFFINITY<br/>[FR] INDOLES TETRACYCLIQUES 3-SUBSTITUES A AFFINITE POUR LE RECEPTEUR DE SEROTONINE
  申请人：SUVEN LIFE SCIENCES LTD

  公开号：WO2004055026A1

  公开（公告）日：2004-07-01

  The present invention relates to novel substituted tetracyclic 3-substituted indoles, represented by general formula (I), its stereoisomers, its radioisotopes, its N-oxides, its polymorphs, its pharmaceutically acceptable salts, its pharmaceutically acceptable solvates, its useful bio-active metabolites and any suitable combination of the above as well as processes for preparing such compounds of the general formula (I), its stereoisomers, its radioisotopes, its N-oxides, its polymorphs, its pharmaceutically acceptable salts, its pharmaceutically acceptable solvates, its useful bio-active metabolites and also includes any suitable combination of the above.

  本发明涉及新型取代四环3-取代吲哚，其通式表示为（I），其立体异构体、放射性同位素、N-氧化物、多晶型、药学上可接受的盐、药学上可接受的溶剂化合物、有用的生物活性代谢物以及上述任何合适的组合，以及制备通式（I）化合物、其立体异构体、放射性同位素、N-氧化物、多晶型、药学上可接受的盐、药学上可接受的溶剂化合物、有用的生物活性代谢物的过程，还包括上述任何合适的组合。
• Tetracyclic 3-substituted indoles having serotonin receptor affinity
  申请人：Ramakrishna Satya Nirogi Venkata

  公开号：US20070142398A1

  公开（公告）日：2007-06-21

  Tetracyclic 3-substituted indoles having serotonin receptor affinity and pharmaceutically acceptable salts thereof.

  四环3-取代吲哚具有血清素受体亲和力及其药学上可接受的盐。
• TETRACYCLIC 3-SUBSTITUTED INDOLES HAVING SEROTONIN RECEPTOR AFFINITY
  申请人：Suven Life Sciences Limited

  公开号：EP1581538A1

  公开（公告）日：2005-10-05
• US7781476B2
  申请人：——

  公开号：US7781476B2

  公开（公告）日：2010-08-24