1-甲氧基-5-甲基-庚-4-烯-3-酮 | 22761-04-2

• 分子结构分类: 有机化合物 - 有机氧化合物
• 中文名称: 1-甲氧基-5-甲基-庚-4-烯-3-酮
• 英文名称: 1-methoxy-5-methyl-hept-4-en-3-one
• 英文别名: 1-Methoxy-5-methyl-hept-4-en-3-on；3-Methyl-7-methoxyhept-3-en-5-one；1-methoxy-5-methylhept-4-en-3-one
• CAS: 22761-04-2
• 化学式: C₉H₁₆O₂
• 分子量: 156.225
• InChiKey: SPBZZLYNFHBCQB-UHFFFAOYSA-N

物化性质

• 沸点：
  110-111 °C(Press: 9 Torr)
• 密度：
  0.9789 g/cm3

计算性质

• 辛醇/水分配系数(LogP)：
  1.6
• 重原子数：
  11
• 可旋转键数：
  5
• 环数：
  0.0
• sp3杂化的碳原子比例：
  0.67
• 拓扑面积：
  26.3
• 氢给体数：
  0
• 氢受体数：
  2

反应信息

• 作为反应物：
  描述：

  1-甲氧基-5-甲基-庚-4-烯-3-酮 在 硫酸 、 sodium acetate 、 mercury(II) sulfate 、 溶剂黄146 作用下， 生成 2-methyl-2-ethyltetrahydropyran-4-one
  参考文献：
  名称：

  Conjugate intra- and intermolecular addition mediated by methoxide anion on polymeric support

  摘要：

  By treatment with methoxide anion on polymeric support (IRA 900), chiral beta -oxo or beta -sulphonylamides 2 bearing an alpha,beta -unsaturated ester gave 3,4-disubstituted pyrrolidin-2-ones 3 as easily separable diastereomeric mixtures in good yield and moderate-to-good stereoselection. The polymeric reagent was also effective in promoting both intermolecular conjugate addition and alkylation reactions. (C) 2000 Published by Elsevier Science Ltd.

  DOI：

  10.1016/s0040-4039(00)01490-8
• 作为产物：
  描述：

  甲醇 、 3-methyl-hept-6-en-4-yn-3-ol 在 mercury(II) sulfate 作用下， 生成 1-甲氧基-5-甲基-庚-4-烯-3-酮
  参考文献：
  名称：

  Nasarow, Izvestiya Akademii Nauk SSSR, Seriya Khimicheskaya, 1940, p. 546,547

  摘要：

  DOI：

文献信息

• The Role of the Medical School in Rural Graduate Medical Education: Pipeline or Control Valve?
  作者：Howard K. Rabinowitz、Nina P. Paynter

  DOI：10.1111/j.1748-0361.2000.tb00468.x

  日期：2000.6

  Abstract: Although rural‐based graduate medical education is critically important in the training of competent rural family physicians, the number of physicians selecting these programs is highly dependent on what happens earlier in the pipeline, i.e, during medical school. Using the experience and outcomes research from Jefferson Medical Colleges Physician Shortage Area Program, as well as from published literature describing six other medical school programs with similar goals, this paper addresses the important role of these programs in substantially increasing the number of physicians interested in rural family practice. Although each of these programs differs in its structure, all contain three core features: a strong institutional mission; the targeted selection of students likely to practice in rural areas, predominantly those with rural backgrounds; and a focus on primary care, especially family practice. Outcomes show that all seven programs have been highly successful. Medical schools, therefore, can have a major impact on the number of rural physicians they produce by acting not only as a pipeline or conduit to residency programs, but also as a control valve, beginning as early as the admissions process. In order to maximize their impact on the supply and training of rural family physicians, rural residency programs should understand, support, collaborate with and help develop medical school programs whose mission is to provide rural physicians.
• Nasarow; Kusnetzowa; Gurwitsch, Zhurnal Obshchei Khimii, 1948, vol. 18, p. 1497
  作者：Nasarow、Kusnetzowa、Gurwitsch

  DOI：——

  日期：——
• Nasarow, Izvestiya Akademii Nauk SSSR, Seriya Khimicheskaya, 1940, p. 556
  作者：Nasarow

  DOI：——

  日期：——
• The Residency Review Committee and Rural Programs
  作者：Mary Alice Parsons、Diane Beebe

  DOI：10.1111/j.1748-0361.2000.tb00466.x

  日期：2000.6