2-[4-[(7-chloroquinolin-4-yl)amino]pentyl-ethylamino]ethanol;4-N-(7-chloroquinolin-4-yl)-1-N,1-N-diethylpentane-1,4-diamine | 1531590-61-0

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 喹啉及其衍生物
• 英文名称: 2-[4-[(7-chloroquinolin-4-yl)amino]pentyl-ethylamino]ethanol;4-N-(7-chloroquinolin-4-yl)-1-N,1-N-diethylpentane-1,4-diamine
• CAS: 1531590-61-0
• 化学式: C36H52Cl2N6O
• 分子量: 655.7
• InChiKey: BNMFZOPEIBJXHG-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  8.59
• 重原子数：
  45
• 可旋转键数：
  17
• 环数：
  4.0
• sp3杂化的碳原子比例：
  0.5
• 拓扑面积：
  76.6
• 氢给体数：
  3
• 氢受体数：
  7

文献信息

• [EN] QUINONE REDUCTASE 2 INHIBITORS FOR USE AS NEUROPROTECTIVE AGENTS<br/>[FR] INHIBITEURS DE LA QUINONE RÉDUCTASE 2 DESTINÉS À ÊTRE UTILISÉS EN TANT QU'AGENTS NEUROPROTECTEURS
  申请人：UNIV DUKE

  公开号：WO2020081678A1

  公开（公告）日：2020-04-23

  Provided herein according to some embodiments is a method of treating acute neural injury in a subject in need thereof, comprising administering to the subject a compound of Formula I or Formula II. Also provided is a method of treating vascular dementia in a subject in need thereof, comprising administering to the subject a compound of Formula I or Formula II. Further provided is a method of treating CNS lupus in a subject in need thereof, comprising administering to the subject a compound of Formula I or Formula II.

  根据某些实施例所提供的是一种治疗急性神经损伤的方法，包括向需要的受试者施用化合物I或化合物II。还提供了一种治疗血管性痴呆的方法，包括向需要的受试者施用化合物I或化合物II。此外，还提供了一种治疗中枢神经系统红斑狼疮的方法，包括向需要的受试者施用化合物I或化合物II。
• Method of treating autoimmune disease by administering antibodies to interleukin-6
  申请人：Fountain Biopharma Inc.

  公开号：US10370443B2

  公开（公告）日：2019-08-06

  The present disclosure provides antibodies that bind to human interleukin-6 (IL6). The antibodies can modulate IL6 signaling and thus used in treatment or prevention of IL6 associated diseases or disorders, particularly inflammatory disorder, rheumatoid arthritis (RA), angiogenesis, and cancer.

  本公开提供了与人类白细胞介素-6（IL6）结合的抗体。这些抗体可调节 IL6 信号传导，因此可用于治疗或预防 IL6 相关疾病或紊乱，尤其是炎症性紊乱、类风湿性关节炎（RA）、血管生成和癌症。
• Methods for inhibiting immunostimulatory DNA associated responses
  申请人：University of Iowa Research Foundation

  公开号：US20020151564A1

  公开（公告）日：2002-10-17

  The invention features methods for inhibiting immunostimulatory DNA-associated immune responses, through the administration of specific compounds of the general class of 9-aminoacridines and 4-aminoquiniolines. The invention also features methods of screening compounds useful in inhibiting immunostimulatory DNA-induced immune responses.

  本发明的特点是通过施用 9-氨基吖啶和 4-氨基喹啉类化合物抑制免疫刺激 DNA 相关免疫反应的方法。本发明还具有筛选有助于抑制免疫刺激 DNA 诱导的免疫反应的化合物的方法。
• METHODS AND COMPOSITIONS FOR DISRUPTING THE EPITHELIAL BARRIER FUNCTION
  申请人：CELLEGY PHARMACEUTICALS, INC.

  公开号：EP0764017A1

  公开（公告）日：1997-03-26
• EP0764017A4
  申请人：——

  公开号：EP0764017A4

  公开（公告）日：1997-08-06