(1S,3'R,5'S)-5'-(benzyloxy)-6'-(benzyloxymethyl)-5,7-dimethoxy-3',4',5',6'-tetrahydro-3H-spiro[isobenzofuran-1,2'-pyran]-3',4'-diol | 1360866-49-4

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 异香豆素
• 英文名称: (1S,3'R,5'S)-5'-(benzyloxy)-6'-(benzyloxymethyl)-5,7-dimethoxy-3',4',5',6'-tetrahydro-3H-spiro[isobenzofuran-1,2'-pyran]-3',4'-diol
• CAS: 1360866-49-4
• 化学式: C₂₉H₃₂O₈
• 分子量: 508.568
• InChiKey: JBJLCRLEIYZTKB-ZVEOZEOGSA-N

物化性质

• 沸点：
  706.2±60.0 °C(predicted)
• 密度：
  1.32±0.1 g/cm3(Temp: 20 °C; Press: 760 Torr)(predicted)

反应信息

• 作为反应物：
  描述：

  (1S,3'R,5'S)-5'-(benzyloxy)-6'-(benzyloxymethyl)-5,7-dimethoxy-3',4',5',6'-tetrahydro-3H-spiro[isobenzofuran-1,2'-pyran]-3',4'-diol 、 乙酸酐 在 吡啶 、 4-二甲氨基吡啶 作用下， 以 二氯甲烷 为溶剂， 反应 4.0h， 以95%的产率得到(1S,3'R,5'R)-5'-(benzyloxy)-6'-(benzyloxymethyl)-5,7-dimethoxy-3',4',5',6'-tetrahydro-3H-spiro[isobenzofuran-1,2'-pyran]-3',4'-diyl Diacetate
  参考文献：
  名称：

  Synthesis of O-Spiro-C-Aryl Glycosides Using Organocatalysis

  摘要：

  An organocatalysis strategy has been developed toward the synthesis of O-spiro-C-aryl glycosides with different configurations in the sugar part. This strategy has been extended to the synthesis of the Papulacandin class of compounds.

  DOI：

  10.1021/jo202353r
• 作为产物：
  描述：

  ((4R,5S)-5-((1R,2R)-1,3-bis-(benzyloxy)-2-hydroxypropyl)-2,2-dimethyl-1,3-dioxolan-4-yl)(2-(hydroxymethyl)-4,6-dimethoxyphenyl)methanone 在 甲醇 、 对甲苯磺酸 作用下， 反应 1.0h， 以43 mg的产率得到(1S,3'R,5'S)-5'-(benzyloxy)-6'-(benzyloxymethyl)-5,7-dimethoxy-3',4',5',6'-tetrahydro-3H-spiro[isobenzofuran-1,2'-pyran]-3',4'-diol
  参考文献：
  名称：

  Synthesis of O-Spiro-C-Aryl Glycosides Using Organocatalysis

  摘要：

  An organocatalysis strategy has been developed toward the synthesis of O-spiro-C-aryl glycosides with different configurations in the sugar part. This strategy has been extended to the synthesis of the Papulacandin class of compounds.

  DOI：

  10.1021/jo202353r