monosodium mono((1-hydroxyethane-1,1-diyl)bis(phosphinate)) | 26053-16-7

• 分子结构分类: 有机化合物 - 有机酸及其衍生物
• 英文名称: monosodium mono((1-hydroxyethane-1,1-diyl)bis(phosphinate))
• 英文别名: 1-hydroxyethane-1,1-bis(H-phosphinate) disodium salt；1-hydroxyethane-1,1-bis(H-phosphinate) disodium
• CAS: 26053-16-7
• 化学式: C₂H₆O₅P₂*2Na
• 分子量: 217.994
• InChiKey: COBHSQLZJUWOQU-UHFFFAOYSA-L

计算性质

• 辛醇/水分配系数(LogP)：
  -4.67
• 重原子数：
  10.0
• 可旋转键数：
  2.0
• 环数：
  0.0
• sp3杂化的碳原子比例：
  1.0
• 拓扑面积：
  100.49
• 氢给体数：
  1.0
• 氢受体数：
  5.0

反应信息

• 作为产物：
  描述：

  [1-bis(trimethylsilyloxy)phosphanyl-1-trimethylsilyloxyethyl]-bis(trimethylsilyloxy)phosphane 在 sodium methylate 作用下， 生成 monosodium mono((1-hydroxyethane-1,1-diyl)bis(phosphinate))
  参考文献：
  名称：

  Issleib, Kurt; Moegelin, Werner; Balszuweit, Arno, Zeitschrift fur Chemie, 1985, vol. 25, # 10, p. 370 - 371

  摘要：

  DOI：

文献信息

• Formation of 1-Hydroxymethylene-1,1-bisphosphinates through the Addition of a Silylated Phosphonite on Various Trivalent Derivatives
  作者：Jade Dussart-Gautheret、Julia Deschamp、Maelle Monteil、Olivier Gager、Thibaut Legigan、Evelyne Migianu-Griffoni、Marc Lecouvey

  DOI：10.1021/acs.joc.0c01182

  日期：2020.11.20

  handled one-pot synthetic procedure was previously developed for the synthesis of bisphosphinates starting from acyl chlorides. Herein, other trivalent derivatives as acid anhydrides and activated esters were tested to form various bisphosphinates. This modulation of the reactivity can be controlled according to the nature of the acid derivative for the use of sensitive and functionalized substrates

  先前已经开发了一种易于处理的一锅合成方法，用于从酰氯开始合成双膦酸酯。本文中，测试了作为酸酐和活化酯的其他三价衍生物以形成各种双次膦酸酯。可以根据酸衍生物的性质来控制反应性的这种调节，以用于敏感的和功能化的底物。
• A convenient one-pot synthesis of 1-hydroxymethylene-1,1-bisphosphinic acids
  作者：Nicolas Guedeney、Jade Dussart、Julia Deschamp、Mouna Ouechtati、Evelyne Migianu-Griffoni、Marc Lecouvey

  DOI：10.1080/10426507.2018.1540001

  日期：2019.5.27

  Abstract A convenient and generalizable procedure has been optimized to access to 1-hydroxymethylene-1,1-bisphosphinate compounds. Several alkyl, including an alendronate bisphosphinate analog, and (hetero)aryl compounds were rapidly obtained in satisfying to excellent yields. A side product could be identified as a phosphino-phosphonate isomer and plausible mechanistic pathways are discussed here

  摘要 一种方便且可推广的程序已被优化以获取 1-羟基亚甲基-1,1-双次膦酸酯化合物。快速获得了几种烷基，包括阿仑膦酸盐双次膦酸盐类似物和（杂）芳基化合物，收率令人满意。副产物可被鉴定为膦基膦酸酯异构体，此处讨论了可能的机制途径。图形概要
• A convenient synthetic route towards <i>H</i>-bisphosphinates
  作者：Jade Dussart、Nicolas Guedeney、Julia Deschamp、Maelle Monteil、Olivier Gager、Thibaut Legigan、Evelyne Migianu-Griffoni、Marc Lecouvey

  DOI：10.1039/c8ob01878b

  日期：——

  A practical generalisable procedure to synthesize hydroxymethylene H-bisphosphinates has been optimised. Unlike previous reports, numerous alkyl (including an alendronate bisphosphinate analogue) or (hetero)aryl compounds were rapidly obtained in satisfactory to excellent yields. A side product could have been identified as a phosphino-phosphonate isomer and plausible mechanistic pathways are proposed

  合成羟基亚甲基H-双次膦酸酯的实用通用方法已得到优化。与以前的报道不同，可以令人满意的高收率快速获得许多烷基化合物（包括阿仑膦酸双次膦酸酯类似物）或（杂）芳基化合物。可以将副产物鉴定为膦膦酸酯异构体，并在此提出了合理的机理途径。此外，检查文献数据，AP ķ一个也进行价值研究。