ethyl 4,5-di-(4-methylphenyl)-1-methylimidazole-2-carboxylate | 489446-68-6

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 唑类
• 英文名称: ethyl 4,5-di-(4-methylphenyl)-1-methylimidazole-2-carboxylate
• 英文别名: ethyl 1-methyl-4,5-bis(4-methylphenyl)imidazole-2-carboxylate
• CAS: 489446-68-6
• 化学式: C₂₁H₂₂N₂O₂
• 分子量: 334.418
• InChiKey: YQYNGUSXZYFPFV-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  4.6
• 重原子数：
  25
• 可旋转键数：
  5
• 环数：
  3.0
• sp3杂化的碳原子比例：
  0.24
• 拓扑面积：
  44.1
• 氢给体数：
  0
• 氢受体数：
  3

反应信息

• 作为产物：
  描述：

  氯甲酸乙酯 、 2-chloro-4,5-di-(4-methylphenyl)-1-methylimidazoline 生成 ethyl 4,5-di-(4-methylphenyl)-1-methylimidazole-2-carboxylate
  参考文献：
  名称：

  Substituted imidazoles as cannabinoid receptor modulators

  摘要：

  本发明涉及使用本发明的化合物作为大麻素-1（CB1）受体的拮抗剂和/或反向激动剂，特别是用于治疗、预防和抑制由大麻素-1（CB1）受体介导的疾病。本发明涉及使用这些新型化合物选择性拮抗大麻素-1（CB1）受体。因此，本发明的化合物在治疗精神病、记忆障碍、认知障碍、偏头痛、神经病理、神经炎症性疾病（包括多发性硬化症和吉兰-巴雷综合征）、病毒性脑炎、脑血管意外和头部创伤的炎症后遗症、焦虑症、压力、癫痫、帕金森病和精神分裂症方面是有用的。这些化合物还可用于治疗物质滥用障碍，特别是对阿片类、酒精和尼古丁的治疗。这些化合物还可用于治疗与过度食物摄入和相关并发症相关的肥胖症或进食障碍。本发明还声明了结构式（I）的新型化合物。

  公开号：

  US20060089356A1

文献信息

• US7057051B2
  申请人：——

  公开号：US7057051B2

  公开（公告）日：2006-06-06
• US7572785B2
  申请人：——

  公开号：US7572785B2

  公开（公告）日：2009-08-11
• [EN] SUBSTITUTED IMIDAZOLES AS CANNABINOID RECEPTOR MODULATORS<br/>[FR] IMIDAZOLES SUBSTITUES SERVANT DE MODULATEURS DE RECEPTEURS DE CANNABINOIDES
  申请人：MERCK & CO INC

  公开号：WO2003007887A2

  公开（公告）日：2003-01-30

  The use of compounds of the present invention as antagonists and/or inverse agonists of the Cannabinoid-1 (CB1)receptor particularly in the treatment, prevention and suppression of diseases mediated by the Cannabinoid-1 (CB1) receptor. The invention is concerned with the use of these novel compounds to selectively antagonize the Cannabinoid-1 (CB1) receptor. As such, compounds of the present invention are useful as psychotropic drugs in the treatment of psychosis, memory deficits, cognitive disorders, migraine, neuropathy, neuro-inflammatory disorders including multiple sclerosis and Guillain-Barre syndrome and the inflammatory sequelae of viral encephalitis, cerebral vascular accidents, and head trauma, anxiety disorders, stress, epilepsy, Parkinson s disease, and schizophrenia. The compounds are also useful for the treatment of substance abuse disorders, particularly to opiates, alcohol, and nicotine. The compounds are also useful for the treatment of obesity or eating disorders associated with excessive food intake and complications associated therewith. Novel compounds of structural formula (I) are also claimed.