4,5-Dihydro-3-hydrazino-6-(4-ethoxyphenyl)-4-(1,3-diphenyl-5-hydrazinopyrazolin-4-yl)pyridazine | 173780-34-2

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 唑类
• 英文名称: 4,5-Dihydro-3-hydrazino-6-(4-ethoxyphenyl)-4-(1,3-diphenyl-5-hydrazinopyrazolin-4-yl)pyridazine
• 英文别名: [4-[6-(4-ethoxyphenyl)-3-hydrazinyl-4,5-dihydropyridazin-4-yl]-2,5-diphenylpyrazol-3-yl]hydrazine
• CAS: 173780-34-2
• 化学式: C₂₇H₂₈N₈O
• 分子量: 480.572
• InChiKey: KNHAYPUQGRGIAK-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  3.98
• 重原子数：
  36.0
• 可旋转键数：
  7.0
• 环数：
  5.0
• sp3杂化的碳原子比例：
  0.15
• 拓扑面积：
  127.87
• 氢给体数：
  4.0
• 氢受体数：
  9.0

反应信息

• 作为反应物：
  描述：

  4,5-Dihydro-3-hydrazino-6-(4-ethoxyphenyl)-4-(1,3-diphenyl-5-hydrazinopyrazolin-4-yl)pyridazine 在 溶剂黄146 、 sodium nitrite 作用下， 反应 1.0h， 以45%的产率得到4,5-Dihydro-6-(4-ethoxyphenyl)-4-<1,3-diphenyl-triazolo<4,5-b>pyrazolin-4-yl>tetrazolo<2,3-b>pyridazine
  参考文献：
  名称：

  Synthesis and biological activity of some new pyridazine derivatives

  摘要：

  Condensation of beta-aroyl-alpha-[1,3-diphenyl-5(4H)-oxo-pyrazol-4-yl] propionic acid with hydrazine hydrate affords 4,5-dihydro-3(2H)-pyridazinone (2). Reaction of 2 with POCl3 and P2S5 gives a dichloro derivative (7) and a dithione (4). The behavior of the dichloro and dithione derivatives toward various reagents was studied. The in vitro antibacterial screening reveals moderate activities against certain bacteria.

  DOI：

  10.1007/bf00824306
• 作为产物：
  描述：

  3-Chloro-4,5-dihydro-6-(4-ethoxyphenyl)-4-(5-chloro-1,3-diphenyl-pyrazolin-4-yl)pyridazine 在 一水合肼 作用下， 以 乙醇 为溶剂， 反应 5.0h， 以67%的产率得到4,5-Dihydro-3-hydrazino-6-(4-ethoxyphenyl)-4-(1,3-diphenyl-5-hydrazinopyrazolin-4-yl)pyridazine
  参考文献：
  名称：

  Synthesis and biological activity of some new pyridazine derivatives

  摘要：

  Condensation of beta-aroyl-alpha-[1,3-diphenyl-5(4H)-oxo-pyrazol-4-yl] propionic acid with hydrazine hydrate affords 4,5-dihydro-3(2H)-pyridazinone (2). Reaction of 2 with POCl3 and P2S5 gives a dichloro derivative (7) and a dithione (4). The behavior of the dichloro and dithione derivatives toward various reagents was studied. The in vitro antibacterial screening reveals moderate activities against certain bacteria.

  DOI：

  10.1007/bf00824306