| 1449751-38-5

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 唑类
• CAS: 1449751-38-5
• 化学式: C₂₅H₂₇N₃O₃
• 分子量: 417.508
• InChiKey: SPNGBFLWNMBILW-UHFFFAOYSA-N

反应信息

• 作为产物：
  描述：

  在 一水合肼 作用下， 以 四氢呋喃 、 二氯甲烷 、 水 为溶剂， 反应 0.5h， 生成
  参考文献：
  名称：

  Correlation between Functionality Preference of Ru Carbenes and exo/endo Product Selectivity for Clarifying the Mechanism of Ring-Closing Enyne Metathesis

  摘要：

  Functionality preferences of metathesis Ru carbenes to various alkenes and alkynes with electronic and steric diversity were determined by using time-dependent fluorescence quenching. The functionality preferences depend not only on the properties of multiple bonds but also on the ligands on Ru. There was a good correlation between functionality preference and the metathesis reaction outcome. The correlation between functionality preference and exo/endo product ratio offers a solution to resolve the mechanistic issue related with alkene- vs alkyne-initiated pathway in ring-closing enyne metathesis. The correlation indicates the preference is likely to dictate the reaction pathway and eventually the outcome of the reaction. The Ru catalyst favoring alkyne over alkene provides more endo product, indicating that the reaction mainly initiates at the alkyne. By changing the substitution pattern, the preference can be reversed to give an exclusive exo product.

  DOI：

  10.1021/jo401420f