(2R,3S)-2-Hydroxymethyl-5-phenyl-tetrahydro-furan-3-ol | 757957-02-1

• 分子结构分类: 有机化合物 - 有机氧化合物
• 英文名称: (2R,3S)-2-Hydroxymethyl-5-phenyl-tetrahydro-furan-3-ol
• 英文别名: (2R,3S)-2-(hydroxymethyl)-5-phenyloxolan-3-ol
• CAS: 757957-02-1
• 化学式: C₁₁H₁₄O₃
• 分子量: 194.23
• InChiKey: LVPXMPVIIAGLBC-KHUXNXPUSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  1.1
• 重原子数：
  14
• 可旋转键数：
  2
• 环数：
  2.0
• sp3杂化的碳原子比例：
  0.45
• 拓扑面积：
  49.7
• 氢给体数：
  2
• 氢受体数：
  3

反应信息

• 作为反应物：
  描述：

  (2R,3S)-2-Hydroxymethyl-5-phenyl-tetrahydro-furan-3-ol 在 三乙基硅烷 、 scandium tris(trifluoromethanesulfonate) 作用下， 以 二氯甲烷 为溶剂， 以51%的产率得到(2R,5S)-5-phenyl-pentane-1,2,3-triol
  参考文献：
  名称：

  Mild Reductive Opening of Aryl Pyranosides Promoted by Scandium(III) Triflate

  摘要：

  DOI：

  10.1021/ja067234o
• 作为产物：
  描述：

  在 四丁基氟化铵 作用下， 以 四氢呋喃 为溶剂， 以85%的产率得到(2R,3S)-2-Hydroxymethyl-5-phenyl-tetrahydro-furan-3-ol
  参考文献：
  名称：

  α-和β-2'-脱氧-杂芳基-C-核苷的高效合成

  摘要：

  通过应用芳基-羟醛缩合，然后对甲苯磺酸 (PTSA) 介导的异亚丙基裂解和随后的环醚化，开发了一种短而有效的合成一系列 2'-脱氧-杂芳基-C-核苷的方法。

  DOI：

  10.1055/s-2008-1072589

文献信息

• Fluorescent nucleoside analogs and combinatorial fluorophore arrays comprising same
  申请人：Research Corporation Technologies, Inc.

  公开号：US20020160411A1

  公开（公告）日：2002-10-31

  The present invention provides fluorescent nucleoside analogs which comprise a fluorescent cyclic compound joined to a carbon of a sugar molecule such as pentose, hexose, ribose or deoxyribose or analogs thereof in either an &agr; or &bgr; configuration. The subject compounds are useful as probes in the study of the structure and dynamics of nucleic acids and their complexes with proteins. In addition, the subject compounds are useful in any technique which uses labeled oligonucleotides for detection. Non-fluorescent spacer molecules in which a cyclohexane, cyclohexene, decalin, or benzene is joined to a carbon of a sugar moiety such as pentose, hexose, ribose or deoxyribose are also provided. Also provided are the 5′ dimethoxytrityl-3′ -O-phosphoramidite derivatives, suitable for incorporation into oligonucleotides by automated synthesizers. Combinatorial fluorophore array (CFA) libraries comprising oligomers of the subject nucleoside analogs attached to one or more solid supports are also provided as are methods of selecting fluorophores from the CFA libraries. The present invention also provides oligonucleotide analogs comprising one or more of the subject nucleoside analogs in place of a DNA or RNA base.

  本发明提供了荧光核苷酸类似物，其包括连接到糖分子（如戊糖，己糖，核糖或去氧核糖或其类似物）的碳上的荧光环状化合物，其处于α或β构型。这些化合物可用作研究核酸及其与蛋白质复合物的结构和动力学的探针。此外，这些化合物在使用标记寡核苷酸进行检测的任何技术中也很有用。还提供了非荧光间隔分子，其中环己烷，环己烯，癸烷或苯连接到糖基中的碳上，例如戊糖，己糖，核糖或去氧核糖。还提供了5'-二甲氧基三脱保护基-3'-O-磷酰胺酯衍生物，适合通过自动合成器合成到寡核苷酸中。还提供了组合荧光染料阵列（CFA）库，其中包括连接到一个或多个固体支撑物上的主题核苷酸类似物的寡聚体，以及从CFA库中选择荧光染料的方法。本发明还提供了寡核苷酸类似物，其中包括一个或多个主题核苷酸类似物代替DNA或RNA碱基。
• Genes identified as required for proliferation in Escherichia coli
  申请人：Elitra Pharmaceuticals, Inc.

  公开号：EP1178052A2

  公开（公告）日：2002-02-06

  The sequences of nucleic acids encoding proteins required for E.coli proliferation are disclosed. The nucleic acids can be used to express proteins or portions thereof, to obtain antibodies capable of specifically binding to the expressed proteins, and to use those expressed proteins as a screen to isolate candidate molecules for rational drug discovery programs. The nucleic acids can also be used to screen for homologous genes that are required for proliferation in microorganisms other than E. coli. The nucleic acids can also be used to design expression vectors and secretion vectors. The nucleic acids of the present invention can also be used in various assay systems to screen for proliferation required genes in other organisms as well as to screen for antimicrobial agents.

  本文公开了编码大肠杆菌增殖所需蛋白质的核酸序列。这些核酸可用于表达蛋白质或其部分，获得能与所表达的蛋白质特异性结合的抗体，并利用这些表达的蛋白质作为筛选物，分离出候选分子，用于合理的药物发现计划。核酸还可用于筛选大肠杆菌以外的微生物增殖所需的同源基因。核酸还可用于设计表达载体和分泌载体。本发明的核酸还可用于各种检测系统，以筛选其他生物体内增殖所需的基因以及筛选抗菌剂。
• Genes identified as required for proliferation of E. coli
  申请人：——

  公开号：US20020022718A1

  公开（公告）日：2002-02-21

  The sequences of nucleic acids encoding proteins required for E. coli proliferation are disclosed. The nucleic acids can also be used to screen for homologous genes that are required for proliferation in microorganisms other than E. coli . The nucleic acids can also be used to design expression vectors and secretion vectors. The nucleic acids can be used to express proteins or portions thereof, to obtain antibodies capable of specifically binding to the expressed proteins, and to use those expressed proteins as a screen to isolate candidate molecules for rational drug discovery programs. The nucleic acids of the present invention can also be used in various assay systems to screen for antimicrobial agents.

  编码大肠杆菌生长所需的蛋白质的核酸序列 大肠杆菌 公开了编码大肠杆菌增殖所需蛋白质的核酸序列。这些核酸还可用于筛选大肠杆菌以外的微生物增殖所需的同源基因。 大肠杆菌 .核酸还可用于设计表达载体和分泌载体。核酸可用于表达蛋白质或其部分，获得能与表达的蛋白质特异性结合的抗体，并利用这些表达的蛋白质作为筛选，分离出候选分子，用于合理的药物发现计划。本发明的核酸还可用于各种检测系统，以筛选抗菌剂。
• Genes identified as required for proliferation in escherichia coli
  申请人：ELITRA PHARMACEUTICALS, INC.

  公开号：US20020045592A1

  公开（公告）日：2002-04-18

  The sequences of nucleic acids encoding proteins required for E. coli proliferation are disclosed. The nucleic acids can be used to express proteins or portions thereof, to obtain antibodies capable of specifically binding to the expressed proteins, and to use those expressed proteins as a screen to isolate candidate molecules for rational drug discovery programs. The nucleic acids can also be used to screen for homologous genes that are required for proliferation in microorganisms other than E. coli. The nucleic acids can also be used to design expression vectors and secretion vectors. The nucleic acids of the present invention can also be used in various assay systems to screen for proliferation required genes in other organisms as well as to screen for antimicrobial agents.

  编码大肠杆菌生长所需的蛋白质的核酸序列 大肠杆菌 公开了编码大肠杆菌增殖所需蛋白质的核酸序列。这些核酸可用于表达蛋白质或其部分，获得能与所表达的蛋白质特异性结合的抗体，并利用这些表达的蛋白质作为筛选物，分离出候选分子，用于合理的药物发现计划。核酸还可用于筛选除大肠杆菌以外的微生物增殖所需的同源基因。 大肠杆菌。 核酸还可用于设计表达载体和分泌载体。本发明的核酸还可用于各种检测系统，以筛选其他生物体内增殖所需的基因以及筛选抗菌剂。
• Identification of essential genes in prokaryotes
  申请人：——

  公开号：US20020061569A1

  公开（公告）日：2002-05-23

  The sequences of antisense nucleic acids which inhibit the proliferation of prokaryotes are disclosed. Cell-based assays which employ the antisense nucleic acids to identify and develop antibiotics are also disclosed. The antisense nucleic acids can also be used to identify proteins required for proliferation, express these proteins or portions thereof, obtain antibodies capable of specifically binding to the expressed proteins, and to use those expressed proteins as a screen to isolate candidate molecules for rational drug discovery programs. The nucleic acids can also be used to screen for homologous nucleic acids that are required for proliferation in cells other than Staphylococcus aureus, Salmonella typhimurium, Klebsiella pneumoniae , and Pseudomonas aeruginosa . The nucleic acids of the present invention can also be used in various assay systems to screen for proliferation required genes in other organisms.

  公开了抑制原核生物增殖的反义核酸序列。还公开了利用反义核酸鉴定和开发抗生素的基于细胞的检测方法。反义核酸还可用于鉴定增殖所需的蛋白质，表达这些蛋白质或其部分，获得能与表达的蛋白质特异性结合的抗体，并利用这些表达的蛋白质作为筛选，分离出候选分子，用于合理的药物发现计划。这些核酸还可用于筛选在金黄色葡萄球菌以外的细胞中增殖所需的同源核酸。 金黄色葡萄球菌、鼠伤寒沙门氏菌、肺炎克雷伯菌 和 铜绿假单胞菌 .本发明的核酸还可用于各种检测系统，以筛选其他生物体的增殖所需基因。