4-亚硝基喹啉1-氧化物 | 1130-69-4

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 喹啉及其衍生物
• 中文名称: 4-亚硝基喹啉1-氧化物
• 英文名称: 4-nitrosoquinoline 1-oxide
• 英文别名: 4-nitrosoquinoline N-oxide；4-Nitrosochinolin-1-oxid；4-nitroso-1-oxidoquinolin-1-ium
• CAS: 1130-69-4
• 化学式: C₉H₆N₂O₂
• 分子量: 174.159
• InChiKey: HDODESNNQIATIS-UHFFFAOYSA-N

物化性质

• 熔点：
  109 °C (decomp)
• 沸点：
  305.12°C (rough estimate)
• 密度：
  1.3146 (rough estimate)

计算性质

• 辛醇/水分配系数(LogP)：
  -0.2
• 重原子数：
  13
• 可旋转键数：
  0
• 环数：
  2.0
• sp3杂化的碳原子比例：
  0.0
• 拓扑面积：
  54.9
• 氢给体数：
  0
• 氢受体数：
  3

反应信息

• 作为反应物：
  描述：

  4-亚硝基喹啉1-氧化物 生成 1-羟基喹啉-4-亚胺盐酸盐
  参考文献：
  名称：

  ABRAMOVITCH R. A.; SMITH E. M., J. HETEROCYCL. CHEM. , 1975, 12, NO 5, 969-972

  摘要：

  DOI：
• 作为产物：
  描述：

  [(4E)-4-hydroxyiminoquinolin-1-yl] acetate;hydrochloride 、 盐酸 生成 4-亚硝基喹啉1-氧化物
  参考文献：
  名称：

  DEMEUNYNCK M.; LHOMME M. F.; LHOMME J., TETRAHEDRON LETT., 1981, 22, NO 33, 3189-3192

  摘要：

  DOI：

文献信息

• Antimutagenic agent
  申请人：SUNTORY LIMITED

  公开号：EP0129031A2

  公开（公告）日：1984-12-27

  Coenzyme A, pyridoxal-5'-phosphoric acid, as well as pantothenic acid and alkali metal or alkaline earth metal salts thereof are active as antimutagenic agents. Mutagenicity if believed to be responsible for most causes of human cancer. and there are certain foods that have proved to contain mutagens. However, their mutagenicity can be sufficiently suppressed by ingesting them together with the compounds listed above. These compounds are either vitamins or their endoforms, and hence can be safely incorporated in foods.

  辅酶 A、吡哆醛-5'-磷酸、泛酸及其碱金属盐或碱土金属盐都具有抗突变剂的活性。诱变性被认为是导致人类癌症的大多数原因。不过，如果与上述化合物一起摄入，就可以充分抑制它们的致突变性。这些化合物要么是维生素，要么是其内含物，因此可以安全地加入食品中。
• Use of coenzyme A as an antimutagenic agent
  申请人：SUNTORY LIMITED

  公开号：EP0242554A2

  公开（公告）日：1987-10-28

  Coenzyme A is active as antimutagenic agent. Mutagenicity is believed to be responsible for most causes of human cancer, and there are certain foods that have proved to contain mutagens. However, their mutagenicity can be sufficiently suppressed by ingesting them together with the compound listed above. This compound is a vitamin, and hence can be safely incorporated in foods.

  辅酶 A 具有抗突变的活性。诱变性被认为是导致人类癌症的大多数原因，而某些食物已被证明含有诱变剂。不过，如果与上述化合物一起摄入，就能充分抑制它们的致突变性。这种化合物是一种维生素，因此可以安全地加入食物中。
• Pantothenic acid as an antimutagenic agent
  申请人：SUNTORY LIMITED

  公开号：EP0248151A1

  公开（公告）日：1987-12-09

  Pantothenic acid and alkali metal or alkaline earth metal salts thereof are active as antimutagenic agents. Mutagenicity is believed to be responsible for most causes of human cancer, and there are certain foods that have proved to contain mutagens. However, their mutagenicity can be sufficiently suppressed by ingesting them together with the compounds listed above. These compounds are either vitamins or their endoforms, and hence can be safely incorporated in foods.

  泛酸及其碱金属或碱土金属盐具有抗突变剂的活性。 突变性被认为是导致人类癌症的大多数原因，某些食品已被证明含有突变剂。 但是，通过与上述化合物一起摄入，可以充分抑制它们的突变性。 这些化合物是维生素或其内含物，因此可以安全地添加到食品中。
• Diagnostic methods for protein profiling
  申请人：Madura Kiran

  公开号：US20050287608A1

  公开（公告）日：2005-12-29

  Methods for establishing a protein expression profile of a biological sample, by contacting a biological sample with a ubiquitin-binding protein such that ubiquitinated and specific non-ubiquitinated protein (the IPS) bind to the ubiquitin-binding protein; isolating the IPS proteins; and analyzing the isolated IPS proteins, wherein an expression profile is generated.

  建立生物样本蛋白质表达谱的方法，通过将生物样本与泛素结合蛋白接触，使泛素化蛋白和特定的非泛素化蛋白（IPS）与泛素结合蛋白结合；分离 IPS 蛋白；分析分离的 IPS 蛋白，从而生成表达谱。
• 1-acetoxy-4-hydroxyimino-1,4-dihydroquinoline, a reactive intermediate derived from the potent carcinogen 4-nitroquinoline N-oxide
  作者：Martine Demeunynck、Marie France Lhomme、Jean Lhomme

  DOI：10.1016/s0040-4039(01)81860-8

  日期：1981.1