5-((3R,9S)-9-hydroxy-7,7-dimethyl-4-(tetrahydro-2H-pyran-4-yl)-2',3',5',6,6',7,8,9-octahydro-3H-spiro[furo[3,4-c]quinoline-1,4'-pyran]-3-yl)-2-(trifluoromethyl)benzonitrile | 1332485-62-7

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 喹啉及其衍生物
• 英文名称: 5-((3R,9S)-9-hydroxy-7,7-dimethyl-4-(tetrahydro-2H-pyran-4-yl)-2',3',5',6,6',7,8,9-octahydro-3H-spiro[furo[3,4-c]quinoline-1,4'-pyran]-3-yl)-2-(trifluoromethyl)benzonitrile
• 英文别名: 5-[(3R,9S)-9-hydroxy-7,7-dimethyl-4-(oxan-4-yl)spiro[3,6,8,9-tetrahydrofuro[3,4-c]quinoline-1,4'-oxane]-3-yl]-2-(trifluoromethyl)benzonitrile
• CAS: 1332485-62-7
• 化学式: C₃₀H₃₃F₃N₂O₄
• 分子量: 542.598
• InChiKey: XKUNWEBXIFHTFM-WXVAWEFUSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  3.8
• 重原子数：
  39
• 可旋转键数：
  2
• 环数：
  6.0
• sp3杂化的碳原子比例：
  0.6
• 拓扑面积：
  84.6
• 氢给体数：
  1
• 氢受体数：
  9

文献信息

• TRICYCLIC PYRIDINE DERIVATIVES, MEDICAMENTS CONTAINING SUCH COMPOUNDS, THEIR USE AND PROCESS FOR THEIR PREPARATION
  申请人：WAGNER Holger

  公开号：US20120046304A1

  公开（公告）日：2012-02-23

  The present invention relates to compounds defined by formula I wherein the variables R 1 -R 8 are defined as in the description, possessing valuable pharmacological activity. Particularly, the compounds are inhibitors of cholesterol ester transfer protein (CETP) and thus are suitable for treatment and prevention of diseases which can be influenced by inhibition of this enzyme.

  本发明涉及由公式I定义的化合物 其中变量R1-R8定义如说明书中所述，具有宝贵的药理活性。特别是，这些化合物是胆固醇酯转移蛋白（CETP）的抑制剂，因此适合用于治疗和预防可以通过抑制该酶而影响的疾病。
• Tricyclic pyridine derivatives, medicaments containing such compounds, their use and process for their preparation
  申请人：Wagner Holger

  公开号：US20130053404A1

  公开（公告）日：2013-02-28

  The present invention relates to compounds defined by formula I wherein the variables R 1 -R 8 are defined as in the description, possessing valuable pharmacological activity. Particularly, the compounds are inhibitors of cholesterol ester transfer protein (CETP) and thus are suitable for treatment and prevention of diseases which can be influenced by inhibition of this enzyme.

  本发明涉及由式I定义的化合物，其中变量R1-R8如描述中所定义，具有有价值的药理活性。特别地，这些化合物是胆固醇酯转移蛋白（CETP）的抑制剂，因此适用于治疗和预防受该酶抑制影响的疾病。
• Pyrazole derivatives, compositions containing such compounds and methods of use
  申请人：Parmee R. Emma

  公开号：US20050272794A1

  公开（公告）日：2005-12-08

  Pyrazoles having a naphthyl group attached are disclosed. The compounds are useful for treating type 2 diabetes and related conditions. Pharmaceutical compositions and methods of treatment are also included.

  揭示了附有萘基团的吡唑类化合物。这些化合物可用于治疗2型糖尿病及相关疾病。还包括药物组合物和治疗方法。
• US9029544B2
  申请人：——

  公开号：US9029544B2

  公开（公告）日：2015-05-12