2,4-difluoro-N-[2-methoxy-5-(5-quinolin-3-yl-imidazo[2,1-b][1,3,4]thiadiazol-2-yl)-pyridin-3-yl]-benzenesulfonamide | 1337918-96-3

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 喹啉及其衍生物
• 英文名称: 2,4-difluoro-N-[2-methoxy-5-(5-quinolin-3-yl-imidazo[2,1-b][1,3,4]thiadiazol-2-yl)-pyridin-3-yl]-benzenesulfonamide
• 英文别名: 2,4-difluoro-N-[2-methoxy-5-(5-quinolin-3-ylimidazo[2,1-b][1,3,4]thiadiazol-2-yl)pyridin-3-yl]benzenesulfonamide
• CAS: 1337918-96-3
• 化学式: C₂₅H₁₆F₂N₆O₃S₂
• 分子量: 550.569
• InChiKey: FMNIWGOLCAGRCS-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  4.4
• 重原子数：
  38
• 可旋转键数：
  6
• 环数：
  6.0
• sp3杂化的碳原子比例：
  0.04
• 拓扑面积：
  148
• 氢给体数：
  1
• 氢受体数：
  11

文献信息

• [EN] IMIDAZOTHIADIAZOLES FOR USE AS KINASE INHIBITORS<br/>[FR] IMIDAZO[1,2-B][1,2,3]THIADIAZOLES EN TANT QU'INHIBITEURS DE LA KINASE PROTÉIQUE OU DE LA KINASE LIPIDIQUE
  申请人：CT NAC INVESTIGACIONES ONCOLOGICAS CNIO

  公开号：WO2011121317A9

  公开（公告）日：2012-03-15
• [EN] IMIDAZO [2,1-B] [1,3,4] THIADIAZOLES AS PROTEIN OR LIPID KINASE INHIBITORS<br/>[FR] IMIDAZO[1,2-B][1,2,3]THIADIAZOLES EN TANT QU'INHIBITEURS DE LA KINASE PROTÉIQUE OU DE LA KINASE LIPIDIQUE
  申请人：CT NAC INVESTIGACIONES ONCOLOGICAS CNIO

  公开号：WO2011121317A1

  公开（公告）日：2011-10-06

  There is provided compounds of formula (I): wherein R1 R2 and R3 have meanings given in the description, and pharmaceutically-acceptable esters, amides, solvates or salts thereof, which compounds are useful in the treatment of diseases in which inhibition of a protein or lipid kinase (e.g. PI3-K, particularly class I PI3K, mTOR and/or Flt3) is desired and/or required, and particularly in the treatment of cancer. The invention also relates to combinations containing such compounds.