3-oxo-3-(phenoxathiin-2-yl)-1-phenylpropyl propyldithiocarbamate | 1227678-49-0

• 分子结构分类: 有机化合物 - 苯丙烷和聚酮 - 直链 1,3-二芳基丙烷
• 英文名称: 3-oxo-3-(phenoxathiin-2-yl)-1-phenylpropyl propyldithiocarbamate
• 英文别名: propyl-dithiocarbamic acid 3-oxo-3-(phenoxathiin-2-yl)-1-phenylpropyl ester；(3-oxo-3-phenoxathiin-2-yl-1-phenylpropyl) N-propylcarbamodithioate
• CAS: 1227678-49-0
• 化学式: C₂₅H₂₃NO₂S₃
• 分子量: 465.661
• InChiKey: RYCVTTKQUQLWLJ-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  6.5
• 重原子数：
  31
• 可旋转键数：
  8
• 环数：
  4.0
• sp3杂化的碳原子比例：
  0.2
• 拓扑面积：
  121
• 氢给体数：
  1
• 氢受体数：
  5

反应信息

• 作为产物：
  描述：

  正丙胺 、 二硫化碳 、 1-(phenoxathiin-2-yl)-3-phenyl-propenone 以 四氢呋喃 为溶剂， 反应 2.0h， 以85%的产率得到3-oxo-3-(phenoxathiin-2-yl)-1-phenylpropyl propyldithiocarbamate
  参考文献：
  名称：

  Facile three-component synthesis of dithiocarbamate derivatives with potent antimicrobial activity

  摘要：

  通过 3-苯基/(4-氯苯基)-1-(吩噁噻-2-基)丙烯酮、胺和二硫化碳的反应，实现了 3-氧代-3-(吩噁噻-2-基)-1-苯基/(4-氯苯基)丙基烷基/芳基二硫代氨基甲酸酯的一步法三组份合成。此外，还筛选了一些化合物对某些特定细菌和真菌的抗菌活性。

  DOI：

  10.3184/030823409x12594282884215

文献信息

• Facile three-component synthesis of dithiocarbamate derivatives with potent antimicrobial activity
  作者：Mohamed S. Behalo、Aly A. Aly

  DOI：10.3184/030823409x12594282884215

  日期：2009.12

  A one-pot three-component synthesis of 3-oxo-3-(phenoxathiin-2-yl)-1-phenyl/(4-chlorophenyl)propyl alkyl/aryl-dithiocarbamate was achieved from the reaction of 3-phenyl/(4-chlorophenyl)-1-(phenoxathiin-2-yl)propenones, amine and carbon disulfide. The antimicrobial activities of some compounds were also screened against some selected bacteria and fungi.

  通过 3-苯基/(4-氯苯基)-1-(吩噁噻-2-基)丙烯酮、胺和二硫化碳的反应，实现了 3-氧代-3-(吩噁噻-2-基)-1-苯基/(4-氯苯基)丙基烷基/芳基二硫代氨基甲酸酯的一步法三组份合成。此外，还筛选了一些化合物对某些特定细菌和真菌的抗菌活性。
• Facile, Three-Component Synthesis of Dithiocarbamate Derivatives With Potent Antimicrobial Activity
  作者：M. S. Behalo、A. A. Aly

  DOI：10.1080/10426500903453300

  日期：2010.10.28

  A one-pot three component synthesis of alkyl/aryl-dithiocarbamic acid-3-oxo-3-(phenoxathiin-2-yl)-1-phenyl/(4-chlorophenyl)propyl esters (3a-n) was achieved from the reaction of 3-phenyl/(4-chlorophenyl)-1-(phenoxathiin-2-yl)propenones (1a,b), amine, and carbon disulfide. The antimicrobial activities of some compounds were also screened against some selected bacteria and fungi. Supplemental materials are available for this article. Go to the publisher's online edition of Phosphorus, Sulfur, and Silicon and the Related Elements to view the free supplemental file.