Neratinib impurity QL | 1469746-91-5

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 喹啉及其衍生物
• 英文名称: Neratinib impurity QL
• 英文别名: (E)-N-[3-cyano-7-ethoxy-4-[4-(pyridin-2-ylmethoxy)anilino]quinolin-6-yl]-4-(dimethylamino)but-2-enamide
• CAS: 1469746-91-5
• 化学式: C₃₀H₃₀N₆O₃
• 分子量: 522.6
• InChiKey: MPIQYQIEOBCLFG-VQHVLOKHSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  4.2
• 重原子数：
  39
• 可旋转键数：
  11
• 环数：
  4.0
• sp3杂化的碳原子比例：
  0.2
• 拓扑面积：
  112
• 氢给体数：
  2
• 氢受体数：
  8

文献信息

• [EN] SUBSTITUTED QUINOLINES AS BRUTON'S TYROSINE KINASES INHIBITORS<br/>[FR] QUINOLÉINES SUBSTITUÉES EN TANT QU'INHIBITEURS DE TYROSINE KINASES DE BRUTON
  申请人：ZHANG DAWEI

  公开号：WO2013152135A1

  公开（公告）日：2013-10-10

  The present invention is directed to novel quinolines, their derivatives, pharmaceutically acceptable salts, solvates and hydrates thereof. The compounds and compositions of the present invention have protein kinases inhibitory activities and are useful for the treatment of protein kinases mediated diseases and conditions. The disclosed substituted quinolines include Bruton's tyrosine kinase (Btk) inhibitors.

  本发明涉及新型喹啉，其衍生物，药用盐，溶剂化合物以及其水合物。本发明的化合物和组合物具有蛋白激酶抑制活性，可用于治疗蛋白激酶介导的疾病和症状。所公开的取代喹啉包括布鲁顿酪氨酸激酶（Btk）抑制剂。
• SUBSTITUTED QUINOLINES AS BRUTON'S TYROSINE KINASES INHIBITORS
  申请人：HangzhouDeRenYuCheng Biotechnology Ltd

  公开号：US20150057312A1

  公开（公告）日：2015-02-26

  The present invention is directed to novel quinolines, their derivatives, pharmaceutically acceptable salts, solvates and hydrates thereof. The compounds and compositions of the present invention have protein kinases inhibitory activities and are useful for the treatment of protein kinases mediated diseases and conditions. The disclosed substituted quinolines include Bruton's tyrosine kinase (Btk) inhibitors.

  本发明涉及新型喹啉及其衍生物、药学上可接受的盐、溶剂和水合物。本发明的化合物和组合物具有蛋白激酶抑制活性，并可用于治疗蛋白激酶介导的疾病和病症。所披露的取代喹啉包括布氏酪氨酸激酶（Btk）抑制剂。
• US9353062B2
  申请人：——

  公开号：US9353062B2

  公开（公告）日：2016-05-31