6,8-Dichloro-1,2,3,4-tetrahydroacridin-9-amine | 365533-79-5

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 喹啉及其衍生物
• 英文名称: 6,8-Dichloro-1,2,3,4-tetrahydroacridin-9-amine
• CAS: 365533-79-5
• 化学式: C₁₃H₁₂Cl₂N₂
• mdl: MFCD17040454
• 分子量: 267.158
• InChiKey: ISUJWDYWYFLQFP-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  4
• 重原子数：
  17
• 可旋转键数：
  0
• 环数：
  3.0
• sp3杂化的碳原子比例：
  0.307
• 拓扑面积：
  38.9
• 氢给体数：
  1
• 氢受体数：
  2

反应信息

• 作为反应物：
  描述：

  6,8-Dichloro-1,2,3,4-tetrahydroacridin-9-amine 在 氢氧化钾 作用下， 以 乙腈 为溶剂， 生成 (6,8-dichloro-1,2,3,4-tetrahydro-acridin-9-yl)-[7-(1,2,3,4-tetrahydro-acridin-9-ylsulfanyl)-heptyl]-amine
  参考文献：
  名称：

  Novel and potent tacrine-related hetero- and homobivalent ligands for acetylcholinesterase and butyrylcholinesterase

  摘要：

  Based upon synthetic and biochemical results, a novel and potent tacrine analogue and heterobivalent analogues of tacrine, were designed. The role played by the amino groups of homo- and heterobivalent ligands in the interaction with the peripheral and catalytic sites of AChE and BuChE were investigated. The syntheses of these materials together with the results of AChE/BuChE inhibition assays are detailed. (C) 2001 Elsevier Science Ltd. All rights reserved.

  DOI：

  10.1016/s0960-894x(01)00294-3
• 作为产物：
  描述：

  2,4-二氯苯胺 在 lithium aluminium tetrahydride 、 sodium azide 、 三氯氧磷 作用下， 以 二苯醚 、 乙醚 、 乙醇 、 水 为溶剂， 反应 31.17h， 生成 6,8-Dichloro-1,2,3,4-tetrahydroacridin-9-amine
  参考文献：
  名称：

  Specific Targeting of Acetylcholinesterase and Butyrylcholinesterase Recognition Sites. Rational Design of Novel, Selective, and Highly Potent Cholinesterase Inhibitors

  摘要：

  Tacrine-based AChE and BuChE inhibitors were designed by investigating the topology of the active site gorge of the two enzymes. The homobivalent ligands characterized by a nitrogen-bridged atom at the tether level could be considered among the most potent and selective cholinesterase inhibitors described to date. The nitrogen-containing homobivalent ligands 3e,g and the sulfur-containing 3h validated the hypothesis of extra sites of interaction in the AChE and BuChE active site gorges.

  DOI：

  10.1021/jm0255668

文献信息

• EP2681554B1
  申请人：——

  公开号：EP2681554B1

  公开（公告）日：2017-08-09
• SAMPLE COLLECTION DEVICES WITH BLOOD STABILIZING AGENTS
  申请人：Hoke Randal A.

  公开号：US20130209985A1

  公开（公告）日：2013-08-15

  Disclosed are devices for collecting and stabilizing blood or plasma and which contain an anti-coagulant, an antiplatelet agent, and a solubilization agent, and which may optionally include at least one other blood stabilization agent. Methods of making and using the devices in clinical medicine are also provided.
• BLOOD COLLECTION DEVICE CONTAINING LYSOPHOSPHOLIPASE INHIBITOR
  申请人：Craft David

  公开号：US20140030754A1

  公开（公告）日：2014-01-30

  Disclosed are collection devices for collecting and stabilizing whole blood or a component thereof, which include a first end and a second end and at least one interior wall defining a reservoir, wherein the reservoir contains a stabilization agent that includes a lysophospholipase (LysoPLA) inhibitor. Also disclosed are methods for making and using the devices.
• US9459187B2
  申请人：——

  公开号：US9459187B2

  公开（公告）日：2016-10-04
• Novel and potent tacrine-related hetero- and homobivalent ligands for acetylcholinesterase and butyrylcholinesterase
  作者：Luisa Savini、Giuseppe Campiani、Alessandra Gaeta、Cesare Pellerano、Caterina Fattorusso、Luisa Chiasserini、James M Fedorko、Ashima Saxena

  DOI：10.1016/s0960-894x(01)00294-3

  日期：2001.7

  Based upon synthetic and biochemical results, a novel and potent tacrine analogue and heterobivalent analogues of tacrine, were designed. The role played by the amino groups of homo- and heterobivalent ligands in the interaction with the peripheral and catalytic sites of AChE and BuChE were investigated. The syntheses of these materials together with the results of AChE/BuChE inhibition assays are detailed. (C) 2001 Elsevier Science Ltd. All rights reserved.