sodium 2,6-anhydro-3-deoxy-D-glycero-D-galacto-non-2-enonate | 138365-83-0

• 分子结构分类: 有机化合物 - 有机氧化合物
• 英文名称: sodium 2,6-anhydro-3-deoxy-D-glycero-D-galacto-non-2-enonate
• 英文别名: sodium;(2R,3R,4S)-3,4-dihydroxy-2-[(1R,2R)-1,2,3-trihydroxypropyl]-3,4-dihydro-2H-pyran-6-carboxylate
• CAS: 138365-83-0
• 化学式: C₉H₁₃O₈*Na
• 分子量: 272.187
• InChiKey: LDRDWVSSQVXXDE-AFJOUCPTSA-M

计算性质

• 辛醇/水分配系数(LogP)：
  -7.54
• 重原子数：
  18.0
• 可旋转键数：
  4.0
• 环数：
  1.0
• sp3杂化的碳原子比例：
  0.67
• 拓扑面积：
  150.51
• 氢给体数：
  5.0
• 氢受体数：
  8.0

反应信息

• 作为产物：
  描述：

  methyl (2,4,5,7,8,9-hexa-O-acetyl-3-deoxy-D-glycero-β-D-galacto-2-nonulopyran-ose)onate 在 三氟甲磺酸三甲基硅酯 、 水 、 sodium methylate 、 三乙胺 作用下， 以 甲醇 、 乙腈 为溶剂， 生成 sodium 2,6-anhydro-3-deoxy-D-glycero-D-galacto-non-2-enonate
  参考文献：
  名称：

  2,3-Didehydro-2-deoxysialic acids structurally varied at C-5 and their behaviour towards the sialidase from Vibrio cholerae

  摘要：

  2,3-Didehydro-2-deoxy-N-trifluoroacetylneuraminic acid (5-trifluoroacetyl-Neu2en) (3) has been synthesised from Neu5Ac2en (1) by hydrazinolysis, to give Neu2en (2), followed by N-trifluoroacetylation. 2,3-Didehydro-2,3-dideoxy-D-glycero-D-galacto-2-nonulopyranoson ic acid (Kdn2en, 8) and 5-azido-2,3-didehydro-2,3,5-trideoxy-D-glycero-D-galacto-2-nonu lopyranosonic acid (5-azido-5-deoxy-Kdn2en, 9) have been prepared from the acetylated methyl esters of Kdn (4) and 5-azido-5-deoxy-Kdn (5) via Zemplén saponification. The behaviour of the above 2,3-didehydro-2-deoxysialic acids towards Vibrio cholerae sialidase has been investigated.

  DOI：

  10.1016/0008-6215(92)84150-q