4-(phenylsulfonamidomethyl)-N-(quinolin-5-yl)benzamide | 1010893-46-5

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 喹啉及其衍生物
• 英文名称: 4-(phenylsulfonamidomethyl)-N-(quinolin-5-yl)benzamide
• 英文别名: 4-{[(phenylsulfonyl)amino]methyl}-N-(quinolin-5-yl)benzamide；4-(benzenesulfonamidomethyl)-N-quinolin-5-ylbenzamide
• CAS: 1010893-46-5
• 化学式: C₂₃H₁₉N₃O₃S
• 分子量: 417.488
• InChiKey: KKXOOQYNBBRJQM-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  3.5
• 重原子数：
  30
• 可旋转键数：
  6
• 环数：
  4.0
• sp3杂化的碳原子比例：
  0.04
• 拓扑面积：
  96.5
• 氢给体数：
  2
• 氢受体数：
  5

文献信息

• [EN] HETEROARYL BENZAMIDES, COMPOSITIONS AND METHODS OF USE<br/>[FR] HÉTÉROARYL BENZAMIDES, COMPOSITIONS ET PROCÉDÉS D'UTILISATION
  申请人：UNIV LELAND STANFORD JUNIOR

  公开号：WO2011011514A1

  公开（公告）日：2011-01-27

  Provided are certain heteroaryl benzamides, compositions, and methods of their manufacture and use.

  提供了某些杂环芳酰苯胺、组合物及其制备和使用方法。
• HETEROARYL BENZAMIDES, COMPOSITIONS AND METHODS OF USE
  申请人：Sutphin Patrick D.

  公开号：US20120225862A1

  公开（公告）日：2012-09-06

  Provided are certain heteroaryl benzamides, compositions, and methods of their manufacture and use.

  提供了某些杂环芳酰苯胺、组成物及其制造和使用方法。
• Methods for selective inhibition of pluripotent stem cells
  申请人：THE MEDICAL COLLEGE OF WISCONSIN, INC.

  公开号：US10316287B2

  公开（公告）日：2019-06-11

  Provided herein are methods of reducing or eliminating undifferentiated pluripotent stem cells, where the methods comprise contacting an effective amount of a compound to a heterogeneous cell population or sample comprising or suspected of comprising differentiated cell types and undifferentiated pluripotent stem cells, whereby the contacting selectively reduces or eliminates undifferentiated pluripotent stem cells from the cell population or sample. Also provided are methods for obtaining a population of stem cell-derived cell types substantially free of undifferentiated pluripotent stem cells as well as isolated populations of such of stem cell-derived cell types.

  本文提供了减少或消除未分化多能干细胞的方法，其中方法包括将有效量的化合物与包括或疑似包括分化细胞类型和未分化多能干细胞的异质细胞群或样本接触，从而选择性地减少或消除细胞群或样本中的未分化多能干细胞。此外，还提供了获得基本不含未分化多能干细胞的干细胞衍生细胞群体以及干细胞衍生细胞分离群体的方法。
• METHODS FOR SELECTIVE INHIBITION OF PLURIPOTENT STEM CELLS
  申请人：The Medical College of Wisconsin, Inc.

  公开号：EP3097186B1

  公开（公告）日：2019-05-08
• SYNTHETIC LETHAL TARGETING OF GLUCOSE TRANSPORT
  申请人：Irwin John

  公开号：US20140128397A1

  公开（公告）日：2014-05-08

  The present invention provides methods for inhibiting growth and proliferation of HIF pathway proficient cells by administering GLUT1 inhibitors of the invention to HIF pathway proficient cells.