(1S,2S,4'R)-1-(4''-azidobutyl)-2-(2',2'-dimethyl-1',3'-dioxolan-4'-yl)-4-methylenecyclohexane-1-carbaldehyde | 1256293-40-9

• 分子结构分类: 有机化合物 - 有机氧化合物
• 英文名称: (1S,2S,4'R)-1-(4''-azidobutyl)-2-(2',2'-dimethyl-1',3'-dioxolan-4'-yl)-4-methylenecyclohexane-1-carbaldehyde
• CAS: 1256293-40-9
• 化学式: C₁₇H₂₇N₃O₃
• 分子量: 321.42
• InChiKey: FVVHTIXNJSBTAE-HLLBOEOZSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  4.16
• 重原子数：
  23.0
• 可旋转键数：
  7.0
• 环数：
  2.0
• sp3杂化的碳原子比例：
  0.82
• 拓扑面积：
  84.29
• 氢给体数：
  0.0
• 氢受体数：
  4.0

反应信息

• 作为反应物：
  描述：

  (1S,2S,4'R)-1-(4''-azidobutyl)-2-(2',2'-dimethyl-1',3'-dioxolan-4'-yl)-4-methylenecyclohexane-1-carbaldehyde 在 三苯基膦 作用下， 以 氘代甲苯 为溶剂， 反应 18.0h， 以63%的产率得到
  参考文献：
  名称：

  Synthesis of a Functionalized 7,6-Bicyclic Spiroimine Ring Fragment of the Spirolides

  摘要：

  The asymmetric synthesis of a functionalized 7,6-spiroimine related to the spirolides is described. Intermolecular Diels-Alder cycloaddition of a chiral trisubstituted dienophile and Danishefsky's diene enabled simultaneous installation of the C7 and C29 stereocenters. Further transformations and late-stage aza-Wittig cyclization afforded the spiroimine in good yield. During this study, an unprecedented 14-membered dialdimine was also obtained.

  DOI：

  10.1021/ol102525w
• 作为产物：
  描述：

  (1S,2S,4'R)-1-(4''-(p-methylbenzenesulfonyloxy)butyl)-2-(2',2'-dimethyl-1',3'-dioxolan-4'-yl)-4-methylenecyclohexane-1-carbaldehyde 在 sodium azide 作用下， 以 N,N-二甲基甲酰胺 为溶剂， 反应 8.0h， 以73%的产率得到(1S,2S,4'R)-1-(4''-azidobutyl)-2-(2',2'-dimethyl-1',3'-dioxolan-4'-yl)-4-methylenecyclohexane-1-carbaldehyde
  参考文献：
  名称：

  Synthesis of a Functionalized 7,6-Bicyclic Spiroimine Ring Fragment of the Spirolides

  摘要：

  The asymmetric synthesis of a functionalized 7,6-spiroimine related to the spirolides is described. Intermolecular Diels-Alder cycloaddition of a chiral trisubstituted dienophile and Danishefsky's diene enabled simultaneous installation of the C7 and C29 stereocenters. Further transformations and late-stage aza-Wittig cyclization afforded the spiroimine in good yield. During this study, an unprecedented 14-membered dialdimine was also obtained.

  DOI：

  10.1021/ol102525w