PT-1-13 | 1467720-76-8

• 分子结构分类: 有机化合物 - 有机氧化合物
• 英文名称: PT-1-13
• 英文别名: 4,7-dichloro-3-hydroxy-3-[2-oxo-2-(3,4,5-trimethoxyphenyl)ethyl]-1H-indol-2-one
• CAS: 1467720-76-8
• 化学式: C₁₉H₁₇Cl₂NO₆
• 分子量: 426.253
• InChiKey: QNQQSRBFZLGDBD-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  3.1
• 重原子数：
  28
• 可旋转键数：
  6
• 环数：
  3.0
• sp3杂化的碳原子比例：
  0.26
• 拓扑面积：
  94.1
• 氢给体数：
  2
• 氢受体数：
  6

文献信息

• [EN] METHODS AND COMPOSITIONS FOR TREATING EWINGS SARCOMA FAMILY OF TUMORS<br/>[FR] MÉTHODES ET COMPOSITIONS PERMETTANT DE TRAITER DES TUMEURS DE LA FAMILLE DU SARCOME D'EWING
  申请人：UNIV GEORGETOWN

  公开号：WO2013155341A1

  公开（公告）日：2013-10-17

  Compounds, compositions and methods relating to EWS-FLIl protein inhibitors are provided. The compounds have utility in the treatment of cancers including the Ewing's sarcoma family of tumors.

  提供与EWS-FLIl蛋白抑制剂相关的化合物、组合物和方法。这些化合物在治疗包括Ewing肉瘤家族在内的癌症中具有用途。
• METHODS AND COMPOSITIONS FOR TREATING EWINGS SARCOMA FAMILY OF TUMORS
  申请人：GEORGETOWN UNIVERSITY

  公开号：US20150051260A1

  公开（公告）日：2015-02-19

  Compounds, compositions and methods relating to EWS-FLI1 protein inhibitors are provided. The compounds have utility in the treatment of cancers including the Ewing's sarcoma family of tumors.
• METHODS AND COMPOSITIONS FOR TREATING CANCER
  申请人：GEORGETOWN UNIVERSITY

  公开号：US20160263086A1

  公开（公告）日：2016-09-15

  Methods and compositions provided herein relate to the treatment of cancer. In some embodiments, the compositions have utility in the treatment of cancers including glioblastoma multiforme and lung cancer.
• US9290449B2
  申请人：——

  公开号：US9290449B2

  公开（公告）日：2016-03-22
• US9511050B2
  申请人：——

  公开号：US9511050B2

  公开（公告）日：2016-12-06