1-[4-(1,1-dioxidoisothiazolidin-2-yl)butyl]-2-ethoxymethyl-7-phenyl-1H-imidazo[4,5-c]quinolin-4-amine | 723265-00-7

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 喹啉及其衍生物
• 英文名称: 1-[4-(1,1-dioxidoisothiazolidin-2-yl)butyl]-2-ethoxymethyl-7-phenyl-1H-imidazo[4,5-c]quinolin-4-amine
• 英文别名: 1-[4-(1,1-Dioxo-1,2-thiazolidin-2-yl)butyl]-2-(ethoxymethyl)-7-phenylimidazo[4,5-c]quinolin-4-amine
• CAS: 723265-00-7
• 化学式: C₂₆H₃₁N₅O₃S
• 分子量: 493.63
• InChiKey: MXACSWLGQWITQZ-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  3.1
• 重原子数：
  35
• 可旋转键数：
  9
• 环数：
  5.0
• sp3杂化的碳原子比例：
  0.38
• 拓扑面积：
  112
• 氢给体数：
  1
• 氢受体数：
  7

文献信息

• ARYL SUBSTITUTED IMIDAZOQUINOLINES
  申请人：Hays S. David

  公开号：US20060111387A1

  公开（公告）日：2006-05-25

  Aryl substituted imidazoquinoline compounds, pharmaceutical compositions containing the compounds, intermediates, and methods of use of these compounds as immunomodulators, for inducing or inhibiting cytokine biosynthesis in animals and in the treatment of diseases including viral, and neoplastic, are disclosed.

  本发明涉及芳基取代咪唑喹啉化合物、含有该化合物的制药组合物、中间体以及将这些化合物用作免疫调节剂的使用方法，用于在动物中诱导或抑制细胞因子生物合成，以及用于治疗包括病毒性和肿瘤性疾病在内的疾病。
• Aryl substituted imidazoquinolines
  申请人：3M Innovative Properties Company

  公开号：US20040147543A1

  公开（公告）日：2004-07-29

  Aryl substituted imidazoquinoline compounds, pharmaceutical compositions containing the compounds, intermediates, and methods of use of these compounds as immunomodulators, for inducing or inhibiting cytokine biosynthesis in animals and in the treatment of diseases including viral, and neoplastic, are disclosed.

  本发明公开了取代芳基咪唑喹啉化合物、包含该化合物的制药组合物、中间体以及使用这些化合物作为免疫调节剂的方法，用于诱导或抑制动物细胞因子生物合成，并用于治疗包括病毒和肿瘤在内的疾病。
• Compositions for stimulation of mammalian innate immune resistance to pathogens
  申请人：The Board of Regents, The University of Texas System

  公开号：US10722573B2

  公开（公告）日：2020-07-28

  Embodiments of the invention are directed to methods of treating, inhibiting or attenuating a microbial infection in an individual who has or is at risk for developing such an infection, comprising the step of administering an effective amount of a StIR composition to the individual.

  本发明的实施方案涉及治疗、抑制或减弱已感染或有感染风险的个体的微生物感染的方法，包括向该个体施用有效量的 StIR 组合物的步骤。
• COMPOSITIONS FOR STIMULATION OF MAMMALIAN INNATE IMMUNE RESISTANCE TO PATHOGENS
  申请人：The Board of Regents of The University of Texas System

  公开号：EP2411521B1

  公开（公告）日：2015-01-14
• METHODS AND COMPOSITIONS FOR ADAPTIVE IMMUNE MODULATION
  申请人：The Board of Regents of The University of Texas System

  公开号：EP3538218A2

  公开（公告）日：2019-09-18