4-hydrazino-2,8-dimethylquinoline dihydrochloride | 1172993-37-1

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 喹啉及其衍生物
• 英文名称: 4-hydrazino-2,8-dimethylquinoline dihydrochloride
• 英文别名: 2,8-Dimethyl-4-hydrazinoquinoline hydrochloride；(2,8-dimethylquinolin-4-yl)hydrazine;hydrochloride
• CAS: 1172993-37-1
• 化学式: C₁₁H₁₃N₃*2ClH
• 分子量: 260.166
• InChiKey: IJVFHFGKSWIQEM-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  2.56
• 重原子数：
  15
• 可旋转键数：
  1
• 环数：
  2.0
• sp3杂化的碳原子比例：
  0.18
• 拓扑面积：
  50.9
• 氢给体数：
  3
• 氢受体数：
  3

反应信息

• 作为反应物：
  描述：

  4-hydrazino-2,8-dimethylquinoline dihydrochloride 在 水 作用下， 以96%的产率得到2,8-二甲基-4-肼基喹啉
  参考文献：
  名称：

  Synthesis and some transformations of 6(8)-substituted 4-hydrazino-2-methylquinolines

  摘要：

  6(8)-Substituted 4-hydrazino-2-methylquinolines were synthesized by reaction of the corresponding 4-chloro-2-methylquinolines with hydrazine hydrate. Reactions of the title compounds with ethyl acetoacetate and acetone gave 2,4-dimethyl-1H-pyrrolo[3,2-c]quinolines and 4-(5-ethoxy-3-methyl-1H-pyrazol-1-yl)-2-methylquinolines.

  DOI：

  10.1134/s107042801003022x
• 作为产物：
  描述：

  4-氯-2,8-二甲基喹啉 在 盐酸 、 肼 作用下， 以 乙醇 、 水 为溶剂， 反应 15.0h， 以90%的产率得到4-hydrazino-2,8-dimethylquinoline dihydrochloride
  参考文献：
  名称：

  Synthesis and some transformations of 6(8)-substituted 4-hydrazino-2-methylquinolines

  摘要：

  6(8)-Substituted 4-hydrazino-2-methylquinolines were synthesized by reaction of the corresponding 4-chloro-2-methylquinolines with hydrazine hydrate. Reactions of the title compounds with ethyl acetoacetate and acetone gave 2,4-dimethyl-1H-pyrrolo[3,2-c]quinolines and 4-(5-ethoxy-3-methyl-1H-pyrazol-1-yl)-2-methylquinolines.

  DOI：

  10.1134/s107042801003022x

文献信息

• Synthesis and some transformations of 6(8)-substituted 4-hydrazino-2-methylquinolines
  作者：A. A. Avetisyan、I. L. Aleksanyan、L. P. Ambartsumyan

  DOI：10.1134/s107042801003022x

  日期：2010.3

  6(8)-Substituted 4-hydrazino-2-methylquinolines were synthesized by reaction of the corresponding 4-chloro-2-methylquinolines with hydrazine hydrate. Reactions of the title compounds with ethyl acetoacetate and acetone gave 2,4-dimethyl-1H-pyrrolo[3,2-c]quinolines and 4-(5-ethoxy-3-methyl-1H-pyrazol-1-yl)-2-methylquinolines.