3-(3-methyl-isoxazol-5-yl)-2-oxo-4-(4-trifluoromethyl-phenyl)-1,2-dihydro-quinoline-6-carbonitrile | 835881-75-9

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 喹啉及其衍生物
• 英文名称: 3-(3-methyl-isoxazol-5-yl)-2-oxo-4-(4-trifluoromethyl-phenyl)-1,2-dihydro-quinoline-6-carbonitrile
• 英文别名: 3-(3-methyl-1,2-oxazol-5-yl)-2-oxo-4-[4-(trifluoromethyl)phenyl]-1H-quinoline-6-carbonitrile
• CAS: 835881-75-9
• 化学式: C₂₁H₁₂F₃N₃O₂
• 分子量: 395.34
• InChiKey: BMJNAORAVWAFBB-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  3.6
• 重原子数：
  29
• 可旋转键数：
  2
• 环数：
  4.0
• sp3杂化的碳原子比例：
  0.1
• 拓扑面积：
  78.9
• 氢给体数：
  1
• 氢受体数：
  7

文献信息

• Derivatives of isosorbide mononitrate and its use as vasodilating agents with reduced tolerance
  申请人：LACER, S.A.

  公开号：US20030225134A1

  公开（公告）日：2003-12-04

  Novel derivatives of isosorbide mononitrate and its pharmaceutically acceptable salts, which have vasodilating activity with a reduced effect of tolerance, of the general formula (I) 1 in which A and B individually represent any of the groups —ONO 2 and -Z-CO—R, wherein Z is an oxygen atom or sulphur atom and R is an alkyl C 1 -C 4 group, an aryl group or an aralkyl group, eventually substituted, or the group 2 in which R 1 is hydrogen, or an alkyl C 1 -C 4 group, an aryl group or an aralkyl group, eventually substituted, with the proviso that one of A or B is always —ONO 2 , but never both of them at the same time, when Z is an sulphur atom R is an alkyl C 1 -C 4 group, an aryl group or an aralkyl group, eventually substituted, and when Z is an oxygen atom R is the group 3

  新型异山梨酯单硝酸酯及其药学上可接受的盐衍生物，具有扩血管活性并减少耐受性影响，其一般式为（I）1，其中A和B分别代表以下任意一组：—ONO2和-Z-CO—R，其中Z为氧原子或硫原子，R为烷基C1-C4基团，芳基基团或芳基烷基基团，可能带有取代基；或者为以下第二组：其中R1为氢，或烷基C1-C4基团，芳基基团或芳基烷基基团，可能带有取代基，但A或B中必须始终有一个为—ONO2，但氧原子为Z时R为第三组。
• Quinolinone derivatives as inhibitors of c-fms kinase
  申请人：Wall J. Mark

  公开号：US20050049274A1

  公开（公告）日：2005-03-03

  The invention is directed to compounds of Formulae I and II: wherein R 1 , R 2 , R 3 , R 5 , R 6 , Y 1 , Y 2 , Y 3 , Y 4 and X are set forth in the specification, as well as solvates, hydrates, tautomers or pharmaceutically acceptable salts thereof, that inhibit protein tyrosine kinases, especially c-fms kinase.

  本发明涉及公式I和II的化合物：其中R1、R2、R3、R5、R6、Y1、Y2、Y3、Y4和X如规范中所示，以及其溶剂化物、水合物、互变异构体或药学上可接受的盐，它们能够抑制蛋白酪氨酸激酶，特别是c-fms激酶。
• DERIVATIVES OF ISOSORBID MONONITRATE, UTILIZATION AS VASODILATOR AGENTS WITH REDUCED TOLERANCE
  申请人：LACER, S.A.

  公开号：EP1120419A1

  公开（公告）日：2001-08-01

  Disclosed are derivatives of isosorbid mononitrate and pharmaceutically acceptable salts thereof which have a vasodilator activity with a reduced tolerance effect, having the general formula (I) wherein A and B represent independently any of the groups NO2 and-CO-R, Z being an atom of oxygen or sulfur, and R being optionally substituted C1-C4 alkyl, aryl or aralkyl group or the group (a) wherein R1 is hydrogen or optionally substituted C1-C4 alkyl, aryl or aralkyl group,so that always either A or B is NO2 but never both at the same time, when Z is a sulfur atom R is optionally substituted C1-C4 alkyl, aryl or aralkyl group, and when Z is an oxygen atom R is the group (a).

  本发明公开了单硝酸异山梨醇酯的衍生物及其药学上可接受的盐，它们具有血管扩张活性，且耐受性降低，其通式为(I)，其中A和B独立地代表NO2和-CO-R基团中的任一基团，Z为氧原子或硫原子，R为任选取代的C1-C4烷基、芳基或芳烷基基团或基团(a)，其中R1为氢或任选取代的C1-C4烷基、芳基或芳烷基基团、当 Z 为硫原子时，R 为任选取代的 C1-C4 烷基、芳基或芳烷基；当 Z 为氧原子时，R 为(a)基团。
• QUINOLINONE DERIVATIVES AS INHIBITORS OF C-FMS KINASE
  申请人：JANSSEN PHARMACEUTICA N.V.

  公开号：EP1660087A2

  公开（公告）日：2006-05-31
• US6858632B2
  申请人：——

  公开号：US6858632B2

  公开（公告）日：2005-02-22