1-(α-Iodoacetoxy)-2-[(3-isopropoxy-4-methoxy-phenyl)ethynyl]-5-isopropoxy-4-methoxybenzene | 215715-46-1

• 分子结构分类: 有机化合物 - 苯类化合物 - 苯酚酯
• 英文名称: 1-(α-Iodoacetoxy)-2-[(3-isopropoxy-4-methoxy-phenyl)ethynyl]-5-isopropoxy-4-methoxybenzene
• 英文别名: [4-Methoxy-2-[2-(4-methoxy-3-propan-2-yloxyphenyl)ethynyl]-5-propan-2-yloxyphenyl] 2-iodoacetate
• CAS: 215715-46-1
• 化学式: C₂₄H₂₇IO₆
• 分子量: 538.379
• InChiKey: GAYVHNXZYCLARJ-UHFFFAOYSA-N

物化性质

• 沸点：
  591.3±50.0 °C(predicted)
• 密度：
  1.43±0.1 g/cm3(Temp: 20 °C; Press: 760 Torr)(predicted)

计算性质

• 辛醇/水分配系数(LogP)：
  5.9
• 重原子数：
  31
• 可旋转键数：
  11
• 环数：
  2.0
• sp3杂化的碳原子比例：
  0.38
• 拓扑面积：
  63.2
• 氢给体数：
  0
• 氢受体数：
  6

反应信息

• 作为反应物：
  描述：

  1-(α-Iodoacetoxy)-2-[(3-isopropoxy-4-methoxy-phenyl)ethynyl]-5-isopropoxy-4-methoxybenzene 在 吡啶 、 三氧化硫 N,N-二甲基甲酰胺络合物 、 三氯化硼 、 N,N-二异丙基乙胺 、 2,3-二氯-5,6-二氰基-1,4-苯醌 作用下， 以 乙醇 、 二氯甲烷 、 N,N-二甲基甲酰胺 为溶剂， 反应 107.0h， 生成 lamellarin α 13,20-disulfate
  参考文献：
  名称：

  Total synthesis and evaluation of lamellarin α 20-Sulfate analogues

  摘要：

  In order to explore the influence of sulfate groups on the bioactivity profiles of marine alkaloids of the lamellarin class, three such alkaloids, lamellarin alpha, lamellarin alpha 13,20-disulfate and lamellarin H, were synthesized and their activities against HIV-1 integrase and cancer cell lines were compared with those of lamellarin alpha 20-sulfate, which is a selective inhibitor of HIV-1 integrase. Lamellarin alpha does not inhibit HIV-1 integrase but shows moderate cytotoxicity with good cell line selectivity. Lamellarin alpha 13,20-disulfate is a moderate inhibitor of both HIV-1 integrase and cancer cell lines. Lamellarin H is a more potent inhibitor of HIV-1 integrase but lacked the specificity required to be medicinally useful. (C) 2002 Elsevier Science Ltd. All rights reserved.

  DOI：

  10.1016/s0968-0896(02)00237-7
• 作为产物：
  描述：

  2-iodo-5-isopropoxy-4-methoxybenzaldehyde 在 四(三苯基膦)钯 4-二甲氨基吡啶 、 copper(l) iodide 、 氨 、 potassium hydrogencarbonate 、 三乙胺 、 间氯过氧苯甲酸 、 N,N'-二环己基碳二亚胺 作用下， 以 甲醇 、 正己烷 、 二氯甲烷 为溶剂， 反应 13.0h， 生成 1-(α-Iodoacetoxy)-2-[(3-isopropoxy-4-methoxy-phenyl)ethynyl]-5-isopropoxy-4-methoxybenzene
  参考文献：
  名称：

  Total synthesis and evaluation of lamellarin α 20-Sulfate analogues

  摘要：

  In order to explore the influence of sulfate groups on the bioactivity profiles of marine alkaloids of the lamellarin class, three such alkaloids, lamellarin alpha, lamellarin alpha 13,20-disulfate and lamellarin H, were synthesized and their activities against HIV-1 integrase and cancer cell lines were compared with those of lamellarin alpha 20-sulfate, which is a selective inhibitor of HIV-1 integrase. Lamellarin alpha does not inhibit HIV-1 integrase but shows moderate cytotoxicity with good cell line selectivity. Lamellarin alpha 13,20-disulfate is a moderate inhibitor of both HIV-1 integrase and cancer cell lines. Lamellarin H is a more potent inhibitor of HIV-1 integrase but lacked the specificity required to be medicinally useful. (C) 2002 Elsevier Science Ltd. All rights reserved.

  DOI：

  10.1016/s0968-0896(02)00237-7

文献信息

• Preparation of fused polycyclic alkaloids by ring closure of azomethine ylides, novel compounds thereof and their use as chemotherapeutic agents
  申请人：——

  公开号：US20030208076A1

  公开（公告）日：2003-11-06

  A method for the preparation of a compound of general Formula: 1 or pharmaceutically acceptable derivatives and salts, racemates, isomers and/or tautomers thereof comprising cyclizing an azomethine ylide of general Formula: 2 wherein A is a cyclic or non-cyclic group; Z is a carbon or a heteroatom; n is selected from 0, 1, 2 or 3; W, X and Y may be the same or different and each are selected from hydrogen; optionally substituted alkyl, alkenyl, alkynyl, amino, alkoxy, alkenoxy, alkynoxy, aryl, alkylthio, heterocyclyl; carboxy, carboxy ester, carboxamido, acyl, acyloxy, mercapto, halogen, nitro, sulfate, phosphate, cyano and optionally protected hydroxy; or W and X, together with the nitrogen and carbon atoms to which they are attached, form a saturated or unsaturated nitrogen containing heterocyclic group which may be optionally substituted or optionally fused to a saturated or unsaturated carbocyclic group, aryl group or heterocyclic group is provided.

  一种制备通式1化合物或其药学上可接受的衍生物、盐、外消旋体、异构体和/或互变异构体的方法，包括环化通式2的偶氮甲基亚胺，其中A是环状或非环状基团；Z是碳或杂原子；n从0、1、2或3中选择；W、X和Y可以相同也可以不同，每个都是氢；可选择取代的烷基、烯基、炔基、氨基、烷氧基、烯氧基、炔氧基、芳基、烷硫基、杂环基；羧基、羧酯、羧酰胺、酰基、酰氧基、巯基、卤素、硝基、硫酸酯、磷酸酯、氰基和可选择保护的羟基；或者W和X与它们所连接的氮和碳原子一起形成饱和或不饱和的含氮杂环基团，该基团可以选择取代或可选择融合到饱和或不饱和的碳环基团、芳基或杂环基团中。
• Aqueous dispersion of fatty acid silver salt particles, method for redispersing fatty acid silver salt particles, photothermographic light-sensitive material, and method for producing the same
  申请人：FUJI PHOTO FILM CO., LTD.

  公开号：EP0962812A1

  公开（公告）日：1999-12-08

  Fatty acid silver salt particles of an aqueous dispersion thereof which are formed by simultaneously adding into a reaction vessel (a) a silver ion-containing aqueous solution or a silver ion-containing water-organic solvent mixed solution and (b) an aqueous solution of an alkali metal salt of a fatty acid, a solution thereof in a water-organic solvent mixed solvent or a solution thereof in an organic solvent, in an amount of at least 10% of the total amount of silver to be added, and the fatty acid silver salt particles formed satisfies all the following characteristics: (1) The average equivalent-sphere diameter of the fatty acid silver salt particles is from 0.1 µm to 0.8 µm; (2) The average ratio of long sides/short sides in main planes of the fatty acid silver salt particles is from 1 to 4; (3) The average aspect ratio of the particle is from 2 to 30; and (4) The average thickness of the particles is from 0.01 µm to 0.20 µm.

  通过同时加入（a）含有银离子的水溶液或含有银离子的水-有机溶剂混合物和（b）脂肪酸的碱金属盐的水溶液，它在水-有机溶剂混合溶剂中的溶液或有机溶剂中的溶液，其添加量至少为要添加的总银量的10％，形成的水分散脂肪酸银盐颗粒，且满足以下所有特征：（1）脂肪酸银盐颗粒的平均等效球直径为0.1微米至0.8微米；（2）脂肪酸银盐颗粒主平面长边/短边的平均比率为1至4；（3）颗粒的平均纵横比为2至30；（4）颗粒的平均厚度为0.01微米至0.20微米。
• Photothermographic material, novel 2,3-dihydrothiazole derivative, and photographic silver halide photosensitive material
  申请人：FUJI PHOTO FILM CO., LTD.

  公开号：EP0838722A2

  公开（公告）日：1998-04-29

  A photothermographic material contains an organic silver salt, a photosensitive silver halide, a reducing agent, a binder, and a compound of the formula: X-L1-D wherein D is an electron donative group of atoms, X is an adsorption promoting group to silver halide, and L1 is a valence bond or a linking group. It has high sensitivity in the red to infrared region and experiences a minimal change of photographic properties under different developing conditions.

  一种光热成像材料含有一种有机银盐、一种光敏卤化银、一种还原剂、一种粘合剂和一种式中化合物：X-L1-D 其中 D 是原子的电子捐献基团，X 是促进卤化银吸附的基团，L1 是价键或连接基团。该产品在红至红外区域具有高灵敏度，在不同的显影条件下，其感光性能的变化极小。
• Recording elements and making methods
  申请人：FUJI PHOTO FILM CO., LTD.

  公开号：EP0911691A1

  公开（公告）日：1999-04-28

  A recording element has on a support a thermographic or photothermographic layer which contains a non-photosensitive organic silver salt, a reducing agent, an optional photosensitive silver halide, and a polymer latex which has been treated with a separation functional polymer or has an ionic conductivity of up to 2.5 mS/cm. The element produces a low fogged image which remains stable during storage.

  记录元件的支架上有一个热成像或光热成像层，该层含有非感光有机银盐、还原剂、可选的感光卤化银和聚合物胶乳，聚合物胶乳已用分离功能聚合物处理过，或具有高达 2.5 mS/cm 的离子电导率。该元件可产生低雾图像，并在储存期间保持稳定。
• A method for preparing non-photo-sensitive fatty acid silver salt grain
  申请人：FUJI PHOTO FILM CO., LTD.

  公开号：EP1063566A1

  公开（公告）日：2000-12-27

  Provided is a method for producing non-photosensitive fatty acid silver salt comprising the steps of reacting a silver ion-containing solution, the solvent of which being a mixture of an organic solvent and water or water, with a solution of an alkali metal salt of a fatty acid, solvent of which being water, organic solvent or a mixture of an organic solvent and water, to obtain a fatty acid silver grain; adding a dispersing agent; and desalting the obtained fatty acid silver dispersion by ultra-filtration; characterized in that pH of the dispersion is kept at 6 or above during a period from a point of time immediately after the addition of the dispersing agent to a point of time an electric conductivity of the filtrate drops below 2000 µS/cm but not lower than 500 µS/cm by the desalting operation. The non- photosensitive fatty acid silver salt thus prepared is excellent in fog preventive property, time-dependent fog preventive property, image stability after heat development and light transmissivity, when applied to a heat-developable photosensitive material.

  本发明提供了一种生产非光敏脂肪酸银盐的方法，包括以下步骤：将含银离子的溶液（其溶剂为有机溶剂和水或水的混合物）与脂肪酸碱金属盐溶液（其溶剂为水、有机溶剂或有机溶剂和水的混合物）反应，得到脂肪酸银颗粒；加入分散剂；用超滤法对得到的脂肪酸银分散液进行脱盐；其特征在于，在加入分散剂后到通过脱盐操作使滤液的电导率降至 2000 µS/cm 以下但不低于 500 µS/cm 的时间段内，分散液的 pH 值保持在 6 或以上。这样制备的非感光脂肪酸银盐在应用于热显影感光材料时，具有优异的防雾性能、随时间变化的防雾性能、热显影后的图像稳定性和透光率。