ethyl (methyl 6,7-dideoxy-α-D-manno-octopyranoside)uronate | 503274-38-2

• 分子结构分类: 有机化合物 - 有机氧化合物
• 英文名称: ethyl (methyl 6,7-dideoxy-α-D-manno-octopyranoside)uronate
• CAS: 503274-38-2
• 化学式: C₁₁H₂₀O₇
• 分子量: 264.276
• InChiKey: ROVFKVPCTBSWEK-OLSRCRKSSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  -1.22
• 重原子数：
  18.0
• 可旋转键数：
  5.0
• 环数：
  1.0
• sp3杂化的碳原子比例：
  0.91
• 拓扑面积：
  105.45
• 氢给体数：
  3.0
• 氢受体数：
  7.0

反应信息

• 作为反应物：
  描述：

  ethyl (methyl 6,7-dideoxy-α-D-manno-octopyranoside)uronate 在 sodium hydroxide 作用下， 反应 1.0h， 以95%的产率得到sodium (methyl 6,7-dideoxy-α-D-manno-octopyranoside)uronate
  参考文献：
  名称：

  Synthesis and biological evaluation of new mannose 6-phosphate analogues

  摘要：

  Three new analogues of mannose 6-phosphate (M6P)-a sulphate and two carboxylates-have been synthesized and their affinity toward the M6P/IGFII receptor evaluated by affinity column chromatography. These compounds display strong binding to the receptor and therefore are new M6P analogues which may find some dermatological applications. for example healing of post-surgical scars. (C) 2002 Elsevier Science Ltd. All rights reserved.

  DOI：

  10.1016/s0968-0896(02)00264-x
• 作为产物：
  描述：

  ethyl [methyl (E)-2,3,4-tri-O-benzyl-6,7-dideoxy-α-D-manno-oct-6-enopyranoside]uronate 在 palladium on activated charcoal 氢气 作用下， 以 乙醇 、 水 为溶剂， 反应 4.0h， 以98%的产率得到ethyl (methyl 6,7-dideoxy-α-D-manno-octopyranoside)uronate
  参考文献：
  名称：

  Synthesis and biological evaluation of new mannose 6-phosphate analogues

  摘要：

  Three new analogues of mannose 6-phosphate (M6P)-a sulphate and two carboxylates-have been synthesized and their affinity toward the M6P/IGFII receptor evaluated by affinity column chromatography. These compounds display strong binding to the receptor and therefore are new M6P analogues which may find some dermatological applications. for example healing of post-surgical scars. (C) 2002 Elsevier Science Ltd. All rights reserved.

  DOI：

  10.1016/s0968-0896(02)00264-x