2-Amino-3,6-dihydro-3,4-dimethylimidazo [4,5-f]quinoline-7-one | 122759-88-0

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 喹啉及其衍生物
• 英文名称: 2-Amino-3,6-dihydro-3,4-dimethylimidazo [4,5-f]quinoline-7-one
• 英文别名: 2-amino-3,4-dimethyl-6H-imidazo[4,5-f]quinolin-7-one
• CAS: 122759-88-0
• 化学式: C₁₂H₁₂N₄O
• 分子量: 228.25
• InChiKey: RCPHYNBSAUITBN-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  0.9
• 重原子数：
  17
• 可旋转键数：
  0
• 环数：
  3.0
• sp3杂化的碳原子比例：
  0.17
• 拓扑面积：
  72.9
• 氢给体数：
  2
• 氢受体数：
  3

文献信息

• Immunostimulatory nucleic acids and cancer medicament combination therapy for the treatment of cancer
  申请人：——

  公开号：US20020156033A1

  公开（公告）日：2002-10-24

  The invention involves administration of an immunostimulatory nucleic acid in combination with a cancer medicament for the treatment or prevention of cancer in subjects. The combination of drugs are administered in synergistic amounts or in various dosages or at various time schedules. The invention also relates to kits and compositions concerning the combination of drugs.

  本发明涉及将免疫刺激核酸与抗癌药物联合使用，用于治疗或预防受试者的癌症。药物组合以协同量或不同剂量或不同时间安排给药。本发明还涉及有关药物组合的试剂盒和组合物。
• Methods for enhancing antibody-induced cell lysis and treating cancer
  申请人：——

  公开号：US20030026801A1

  公开（公告）日：2003-02-06

  The invention relates to methods and products for treating cancer. In particular the invention relates to combinations of nucleic acids and antibodies for the treatment and prevention of cancer. The invention also relates to diagnostic methods for screening cancer cells.

  本发明涉及治疗癌症的方法和产品。特别是本发明涉及用于治疗和预防癌症的核酸和抗体组合。本发明还涉及筛查癌细胞的诊断方法。
• METHODS FOR ENHANCING ANTIBODY-INDUCED CELL LYSIS AND TREATING CANCER
  申请人：UNIVERSITY OF IOWA RESEARCH FOUNDATION

  公开号：EP1296714A2

  公开（公告）日：2003-04-02
• Combination of CpG and antibodies directed against CD19,CD20, CD22 or CD40 for the treatment or prevention of cancer.
  申请人：UNIVERSITY OF IOWA RESEARCH FOUNDATION

  公开号：EP1296714B1

  公开（公告）日：2009-08-26
• US7534772B2
  申请人：——

  公开号：US7534772B2

  公开（公告）日：2009-05-19