trans-2-Hydroxy-cycloheptan-essigsaeure-lacton | 156406-74-5

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 内酯类
• 英文名称: trans-2-Hydroxy-cycloheptan-essigsaeure-lacton
• 英文别名: (3aS,8aR)-3,3a,4,5,6,7,8,8a-octahydrocyclohepta[b]furan-2-one
• CAS: 156406-74-5
• 化学式: C₉H₁₄O₂
• 分子量: 154.209
• InChiKey: BLYGHAHUKQLNAC-JGVFFNPUSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  2.1
• 重原子数：
  11
• 可旋转键数：
  0
• 环数：
  2.0
• sp3杂化的碳原子比例：
  0.89
• 拓扑面积：
  26.3
• 氢给体数：
  0
• 氢受体数：
  2

反应信息

• 作为产物：
  描述：

  (3aR,8aS)-3,3-dichloro-4,5,6,7,8,8a-hexahydro-3aH-cyclohepta[b]furan-2-one 、 乙酸乙酯 、 溶剂黄146 生成 trans-2-Hydroxy-cycloheptan-essigsaeure-lacton
  参考文献：
  名称：

  BLACK, T. HOWARD;MCDERMOTT, TODD S.;EISENBEIS, SHANE A., TETRAHEDRON LETT., 31,(1990) N6, C. 6617-6620

  摘要：

  DOI：

文献信息

• Diastereocontrol for Highly Enantioselective Carbon-Hydrogen Insertion Reactions of Cycloalkyl Diazoacetates
  作者：Michael P. Doyle、Alexey B. Dyatkin、Gregory H. P. Roos、Fina Canas、Deborah A. Pierson、Arjan van Basten、Paul Mueller、Philippe Polleux

  DOI：10.1021/ja00089a062

  日期：1994.5

  Intramolecular carbon-hydrogen insertion of metal carbenes generated by catalytic diazo decomposition of diazocarbonyl compounds is a facile methodology for carbon-carbon bond formation.1-3 Although there are notable exceptions,& five- membered-ring formation is preferred,7J and regioselectivity is generally subject to defined electronic effects.9JO Enantiocontrol has recently been achieved with selected

  通过重氮羰基化合物的催化重氮分解产生的金属卡宾的分子内碳氢插入是形成碳碳键的简便方法。 1-3 尽管有明显的例外，但优选五元环形成，7J 和区域选择性是通常受确定的电子效应影响。9JO 最近通过使用手性或同手性二铑 (I1) 羧酰胺、11J2 或羧酸盐、~~J~ 但即使使用四[甲基] 二铑 (I1)
• Recyclable polymers based on ring-fused gamma-butyrolactones
  申请人：Colorado State University Research Foundation

  公开号：US10759899B2

  公开（公告）日：2020-09-01

  The invention discloses a class of new polymers, trans-ring-fused poly(4-hydroxybutyrate)s (RF-P4HB) that exhibit a unique set of properties, including robust thermal stability and mechanical strength, quantitative recyclability to the building block monomers via thermolysis and/or chemical catalysis, and convenient production from the chemical ring-opening polymerization under ambient temperature and pressure. Another unique property is the formation of crystalline stereocomplexed polymers with high melting temperature upon mixing the two enantiomeric RF-P4HB chains via stereocomplexing co-crystallization. This invention also provides the corresponding ring-fused lactone monomer structures that enable the synthesis of the RF-P4HB polymers, through trans-fusing of rings to the parent γ-butyrolactone ring. Furthermore, a polymerization or copolymerization process for the synthesis of RF-P4HB polymers and copolymers is disclosed.

  本发明公开了一类新型聚合物--反式环融聚（4-羟基丁酸酯）（RF-P4HB），该聚合物具有一系列独特的性能，包括强大的热稳定性和机械强度，可通过热分解和/或化学催化定量回收为结构单元，以及可在环境温度和压力下通过化学开环聚合反应方便地生产。本发明的另一个独特性质是，通过立体共混共结晶将两种对映异构体 RF-P4HB 链混合后，可形成具有高熔点的结晶立体共混聚合物。本发明还提供了相应的环融内酯单体结构，通过环与母体γ-丁内酯环的反式融合，可合成 RF-P4HB 聚合物。此外，还公开了一种用于合成 RF-P4HB 聚合物和共聚物的聚合或共聚工艺。
• FRISTAD, W. E.;PETERSON, J. R., J. ORG. CHEM., 1985, 50, N 1, 10-18
  作者：FRISTAD, W. E.、PETERSON, J. R.

  DOI：——

  日期：——
• RECYCLABLE POLYMERS BASED ON RING-FUSED GAMMA-BUTYROLACTONES
  申请人：Colorado State University Research Foundation

  公开号：US20190040191A1

  公开（公告）日：2019-02-07

  The invention discloses a class of new polymers, trans-ring-fused poly(4-hydroxybutyrate)s (RF-P4HB) that exhibit a unique set of properties, including robust thermal stability and mechanical strength, quantitative recyclability to the building block monomers via thermolysis and/or chemical catalysis, and convenient production from the chemical ring-opening polymerization under ambient temperature and pressure. Another unique property is the formation of crystalline stereocomplexed polymers with high melting temperature upon mixing the two enantiomeric RF-P4HB chains via stereocomplexing co-crystallization. This invention also provides the corresponding ring-fused lactone monomer structures that enable the synthesis of the RF-P4HB polymers, through trans-fusing of rings to the parent γ-butyrolactone ring. Furthermore, a polymerization or copolymerization process for the synthesis of RF-P4HB polymers and copolymers is disclosed.